DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a14

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001101699.2	Gene:	Slc16a14 / 316578	RGDID:	1309675	Length:	512	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	111/495 - (22%)
Similarity:	205/495 - (41%)	Gaps:	99/495 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KEPPD-GGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGT 134
            |..|| .|..||::::|:|..:.:|.|.....||::....:..     .::....|.:.:|::|.
  Rat    25 KPHPDIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEF-----HQSRGLTAWVSSLSMGI 84

  Fly   135 TFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTL 199
            |.:.....|...:..|.|.|...||::::.|.:||::.. |:.:|:.|:|:..|||:.:||.|.:
  Rat    85 TLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAA-NVQSLFITFGVAAGLGSGMAYLPAV 148

  Fly   200 AILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKP 264
            .::|.||::......|..|.|:...|.::...|..|...||....:.|...:|..:.:|..:.:|
  Rat   149 VMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSLNLCVCGALMRP 213

  Fly   265 LHPP------------------------------PEPPKKKPG-------------------RSR 280
            |.|.                              .|...::||                   |..
  Rat   214 LSPEKVENCSGAEEPCALPAYSTESVKSGGPLDMTEEQDRRPGNEETVCDLQTQELQGQTHPRKN 278

  Fly   281 INLF--LRSI--INVEIWKRKR--------------------FVIWALCVPLALFGYFVPYVHMM 321
            :..|  |:::  :.|.:.:..|                    |:.|||   .|...:.:|::|:.
  Rat   279 VCAFRVLKTVGQLTVRVQRGFRDWHSGYFGTASLFTNRMFVAFIFWAL---FAYSSFVIPFIHLP 340

  Fly   322 QFV--------KTTFPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTL 378
            :.|        ...||...:      |.|....|::|.|.:||:|.::...:..::..::.|...
  Rat   341 EIVSLYNLSEQNDAFPLTSI------IAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIF 399

  Fly   379 LLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAG 443
            ||||.::|..|.....::|...|.| ||:..:..::.|......|.|.::..:.|...:|||.||
  Rat   400 LLPLMHTYASLAVICALIGFSSGYF-SLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAG 463

  Fly   444 MIFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVK-EEENG 482
            .|||.|..|.....:.||..::|...|.:..|:: .|::|
  Rat   464 WIFDITQKYDFSFYICGLLYMVGILFLLIQPCIQMTEQSG 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	99/458 (22%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	82/395 (21%)
Slc16a14	NP_001101699.2	MFS_MCT14	35..494	CDD:340987	104/474 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820