DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kar and Slc16a12

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001178566.1	Gene:	Slc16a12 / 309525	RGDID:	1311468	Length:	486	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	142/518 - (27%)
Similarity:	217/518 - (41%)	Gaps:	112/518 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PPDGGARAWLVMVSAFL----------CNGIIFGFINTY--------GVIHSLLTDRLTKLGDPE 119
            ||||| ..|:::...||          |..|.|....||        ..|||:: |.:|.|..|
  Rat    12 PPDGG-WGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIV-DCMTMLCAP- 73

  Fly   120 ASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYG 184
                             |.|.::..|:.:.|:.|    ||:|::.||:|.||.| ::..||.:.|
  Rat    74 -----------------LGSVVSNQLSCQAGIML----GGLLASTGLILGSFAT-SLKHLYLSLG 116

  Fly   185 IMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMS 249
            ::.|||.||.|:|.:|::|.||.|......|...:||.:.|.||.|.:..|:..:...|.|.|:.
  Rat   117 VLTGLGFALCYSPAIAMVGKYFSRRKAFAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILG 181

  Fly   250 LVSAFIILCSFVYKP--LHPPPEPPKKKPGRSRINLFLR-----SIINVEIWKRKR--------- 298
            .....:.:|..:.:|  |...|..|:|...|.......:     |.:..| |...|
  Rat   182 GFVLNLCVCGALMRPITLKEDPSGPEKSHDRDAQREDCKQASPYSPLTKE-WTETRLCCSLQQGY 245

  Fly   299 -------FVIWAL--------CVPLALFGYFVPYV-------HMMQFVKTTFPGEDVNLPVMCIG 341
                   ||:.|:        |.|  ||.|.|||.       |...|:            :..:|
  Rat   246 GFLLMSDFVVLAVSVLFMAYGCSP--LFVYLVPYALSVGVSHHQAAFL------------MSILG 296

  Fly   342 ITSGIGRLIFGVIADMPGV-NRMYLQQLSLVSI-GLVTLLLPLTNSYVILVSFTLVMGLFDGCFI 404
            :...:|.:.||.:.|...: |..|:..|..|:: ||..|.||:..|:.:||.|:...|.|||.::
  Rat   297 VIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQSFPLLVPFSCTFGYFDGAYV 361

  Fly   405 SLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSL 469
            :|:..:..||.|.:..:.|:|.:..|.::|..|.||:||.:.|:|.|||...:|.|...:..|.|
  Rat   362 TLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSIL 426

  Fly   470 LFLIKCVKEEENGV-------SAPRAVVLANGDI--EIAGNGHYRSAGTKSSAPLMGATNGIN 523
            |...|..|..:...       |.|:..:..||.:  .||     :....|....|..|..|.|
  Rat   427 LGFAKIAKRMKRTQVPFLVKDSDPKLHLWTNGSVAYSIA-----KELDQKDEESLAKARTGCN 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	119/435 (27%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	95/354 (27%)
Slc16a12	NP_001178566.1	2A0111	12..451	CDD:331689	132/478 (28%)
Slc16a12	NP_001178566.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..221		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720