DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a6

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_006247682.2	Gene:	Slc16a6 / 303772	RGDID:	735117	Length:	606	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	109/525 - (20%)
Similarity:	205/525 - (39%)	Gaps:	128/525 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PSAPVQNGNGNANGTHIEAPCC--RDIHGKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHS 106
            |..|.:.|...:..|...:..|  .::: .:.|||| ..|:|..|.|......:|.|.::||..:
  Rat    72 PPRPAETGCSRSRMTQKNSKLCSRANVY-TQVPDGG-WGWVVAASFFFIEVFTYGVIKSFGVFFN 134

  Fly   107 LLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSF 171
            .|.|..     .|::||.:.|.::.:......:.::..||::.|.||....||:|.:.|::.:||
  Rat   135 DLMDSF-----DESNSKISWIISICVFIMTFTAPLSTILTNRFGHRLVVMGGGLLISVGMIAASF 194

  Fly   172 CTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLL 236
             ::.:..:|.:.||:.|||...::.||:.||..||.:....|:...:.|.........|.:..|.
  Rat   195 -SQRVYQMYISIGIVSGLGYCFSFLPTVTILSQYFDKRRSMVTAVASTGECFAMFAFAPAITALK 258

  Fly   237 GSYGLEGTLRIMSLVSAFIILCSFVYKPL------HP---PPEP--------------------- 271
            ...|...:|..:.|:...:::|..:.:|:      .|   |.||
  Rat   259 EHIGWRYSLLFVGLLQLNVMVCGALLRPIIIKGPGSPKAIPLEPRREVQYMLENEKTRTSIDSID 323

  Fly   272 --------PKKKPGRSRINLFLR------------------SIINVEIWKRKRFVIWALCVPLAL 310
                    ||..|..::....:|                  .:::..|.|.:.|:.:.|....|.
  Rat   324 SGVELTTSPKNVPSEAKREQEVRVEQQQTLVVGPKHSQKRAPLLDFSILKDRSFICYTLFGLFAT 388

  Fly   311 FGYFVPYVHMMQFVKTTFPGEDVNLPVMCIGITSGI------------------GRLIFGVIADM 357
            .|:|.|                 :|.::.:||:.||                  ||:..|::.:.
  Rat   389 LGFFAP-----------------SLYIIPLGISLGIHPDRAAFLLSTMAIAEVFGRIGMGLVLNR 436

  Fly   358 PGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFT--------LVMGLFDGCFISLLG----PI 410
            ..:.::|::   |:.:.|:|         |.|.:||        ::..:|.|..:..:|    |:
  Rat   437 EPIRKIYIE---LICVILLT---------VSLFAFTFATEFWGLMLCSVFFGSMVGTIGGTHIPL 489

  Fly   411 AYE--ICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLI 473
            ..|  :.|....:.|.|..:.:.||....|||:||::.|.:..|:...........|.:..|.|:
  Rat   490 LAEDDVVGIEKMSSAAGVYVFIQSISGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALV 554

  Fly   474 K-CVK 477
            : |.|
  Rat   555 RPCKK 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	95/465 (20%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	75/402 (19%)
Slc16a6	XP_006247682.2	MFS_MCT7	108..555	CDD:340980	98/481 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820