DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a13

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001005530.1	Gene:	Slc16a13 / 287451	RGDID:	1359138	Length:	428	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	120/445 - (26%)
Similarity:	205/445 - (46%)	Gaps:	43/445 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 IHGKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAI 132
            :|..|||||| ..|:|::|||..:.::||.:.::||.........     .|.:::.:.|.::.|
  Rat     2 VHRTEPPDGG-WGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAF-----EEQAARVSWIASIGI 60

  Fly   133 GTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTP 197
            ......|.:...|:.|:|.|.....||:|:|.|:||:||.| ::..||.:.|::.|.|.||.:||
  Rat    61 AVQQFGSPIGSALSTKLGPRPVVMTGGILAALGMLLASFAT-SLTHLYLSIGLLSGSGWALTFTP 124

  Fly   198 TLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVY 262
            |||.|..||.:......|....|..:.:....|....||.:|...|.|.::|.:|..::.|..:.
  Rat   125 TLACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLLNNYAWRGALLLVSALSLHLVACGALL 189

  Fly   263 KPLHPPPEPPKKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTT 327
            :||....:.....|.....:|....          .|:.:.:.:.|...|||:||||::..::..
  Rat   190 RPLSLTEDTAVGGPWAQITSLLCHG----------PFLRYTVALTLINTGYFIPYVHLVAHLQDL 244

  Fly   328 FPGEDVNLPVMCI----GITSGIGRLIFGVIAD-MPG-VNRMYLQQLSLVSIGLVTLLLPLTNSY 386
              |.| .||...:    .|:..:||:..|.:.| :|| |.|:.:...:|..:.|.  |.|:..:.
  Rat   245 --GWD-PLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLA--LFPVAQAS 304

  Fly   387 VILVSFTLVMGLFDGCFISLLGPIAY----EICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFD 447
            ..||...:..|...|.    |.|:|:    |:.|.......:|.:..:.|:...:|.|::|.:.|
  Rat   305 TTLVVLAVAYGFTSGA----LTPVAFSVIPELVGTGRIYCGLGLVQMIESVGGLLGAPLSGYLRD 365

  Fly   448 STNSYTLPLILAGLPPLLGSSLLFLI----KCVKEEENGVSAPRAVVLANGDIEI 498
            .|.:||...::||...|.||.:|..:    .|:   ....|.|:.:|:...|.:|
  Rat   366 VTGNYTASFVVAGAFLLAGSGVLITLPHFFSCI---SLSTSRPQDLVIEAPDTKI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	101/387 (26%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	84/324 (26%)
Slc16a13	NP_001005530.1	MFS_MCT11_13	13..392	CDD:340981	107/403 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720