DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a1

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_036848.1	Gene:	Slc16a1 / 25027	RGDID:	3690	Length:	494	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	118/493 - (23%)
Similarity:	201/493 - (40%)	Gaps:	61/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GKEPPDGGARAWLVMVSAFLCNGIIFG-------FINTYGVIHSLLTDRLTKLGDPEASSKAALI 127
            |..||||| ..|.|:|.||:..|..:.       |.....:|.|..|            |:.:.|
  Rat    10 GYTPPDGG-WGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATT------------SEVSWI 61

  Fly   128 GALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAA 192
            .::.:...:....::..|.:|.|.|....|||.||..||:.:||| ..:..|||..|::.|||.|
  Rat    62 SSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFC-NTVQELYFCIGVIGGLGLA 125

  Fly   193 LAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIIL 257
            ....|.|.::|.||.:.....:|...|||.||...|.|......|.:|..|:..|:..:.....:
  Rat   126 FNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCV 190

  Fly   258 CSFVYKPLHPPP---EPPKKK-------------------PGRSRINLF--LRSIINVEIWKRKR 298
            ...:.:|:.|..   |..|.|                   |...::::|  :...:::.::..:.
  Rat   191 AGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRG 255

  Fly   299 FVIWALCVPLALFGYFVPYVHMMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIAD----MP 358
            |:::.....:..||.|.|.|.:..:.|:. |..|.....:..:.....:.|...|:.|:    .|
  Rat   256 FLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRP 320

  Fly   359 GVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQA 423
            .|  .|....|:|:.|:..||.||:.:||....:..|.|...|...|:|.....::.||...:.|
  Rat   321 RV--QYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSA 383

  Fly   424 IGFLLGLSSIPLTVGPPVAGMIFDSTNSYT-------LPLILAGLPPLLGSSLLFLIKCVKEEEN 481
            :|.:..:...|:.:|||:.|.:.|....|.       :.||:|||...:|..:.:  :.|.:|:.
  Rat   384 VGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINY--RLVAKEQK 446

  Fly   482 GVSAPRAVVLANGDIEIAGNGHYRSAGTKSSAPLMGAT 519
            .....|.........::..........|:|.|||..::
  Rat   447 AEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSS 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	100/420 (24%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	81/343 (24%)
Slc16a1	NP_036848.1	2A0113	1..462	CDD:273325	113/469 (24%)
Slc16a1	NP_036848.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..494		6/39 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820