DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a12

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_766426.1	Gene:	Slc16a12 / 240638	MGIID:	2147716	Length:	486	Species:	Mus musculus

Alignment Length:	519	Identity:	138/519 - (26%)
Similarity:	220/519 - (42%)	Gaps:	114/519 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PPDGGARAWLVMVSAFL----------CNGIIFGFINTY--------GVIHSLLTDRLTKLGDPE 119
            ||||| ..|:::...||          |..|.|....||        ..|||:: |.:|.|..|
Mouse    12 PPDGG-WGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIV-DCMTMLCAP- 73

  Fly   120 ASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYG 184
                             |.|.::..|:.:.|:.|    ||:|::.|.:|.||.| ::..||.:.|
Mouse    74 -----------------LGSVVSNQLSCQAGIML----GGLLASTGFILGSFAT-SLKHLYLSLG 116

  Fly   185 IMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMS 249
            ::.|||.||.|:|.:|::|.||.|......|...:||.:.|.||.|.:..|:..:...|.|.|:.
Mouse   117 VLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILG 181

  Fly   250 LVSAFIILCSFVYKPL------------H------------PPPEPPKKKPGRSRINLFLRSIIN 290
            .....:.:|..:.:|:            |            .|..|..|:...:|:...|:....
Mouse   182 GFVLNLCVCGALMRPITLKEDRSVPEKNHNRESQREDCKQASPYSPLTKECTETRLCCSLQQEYG 246

  Fly   291 VEIWKRKRFVIWAL--------CVPLALFGYFVPYV-------HMMQFVKTTFPGEDVNLPVMCI 340
            ..:  ...||:.|:        |.|  ||.|.|||.       |...|:            :..:
Mouse   247 FLL--MSDFVVLAVSVLFMAYGCSP--LFVYLVPYALSVGVSHHQAAFL------------MSIL 295

  Fly   341 GITSGIGRLIFGVIADMPGV-NRMYLQQLSLVSI-GLVTLLLPLTNSYVILVSFTLVMGLFDGCF 403
            |:...:|.:.||.:.|...: |..|:..|..|:: ||..|.||:..::.:||.|:...|.|||.:
Mouse   296 GVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAY 360

  Fly   404 ISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSS 468
            ::|:..:..||.|.:..:.|:|.:..|.::|..|.||:||.:.|:|.|||...:|.|...:..|.
Mouse   361 VTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSI 425

  Fly   469 LLFLIKCVKEEENGV-------SAPRAVVLANGDI--EIAGNGHYRSAGTKSSAPLMGATNGIN 523
            ||..::.||..:...       |.|:..:..||.:  .:|     |....|...||..|.:|.|
Mouse   426 LLGFVRIVKRMKRTQVPFPVKDSDPKLQLWTNGSVAYSVA-----RELDQKDEEPLPKARSGCN 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	114/436 (26%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	90/355 (25%)
Slc16a12	NP_766426.1	MFS_MCT12	18..431	CDD:340982	119/452 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720