Protein Alignment kar and SLC16A8

DIOPT Version :9

• Sequence 1: NP_001189213.1
• Gene: kar / 45883
• FlyBaseID: FBgn0001296
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_037488.2
• Gene: SLC16A8 / 23539
• HGNCID: 16270
• Length: 504
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 128/487 - (26%)
• Similarity: 212/487 - (43%)
• Gaps: 77/487 - (15%)

  Fly    70 GKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEAS-SKAALIGALAIG 133
            |:.||||| ..|:|:.:.|:..|..:||.....|....|      :.|.:|. |..|.:.::.:.
Human     9 GEGPPDGG-WGWVVLGACFVVTGFAYGFPKAVSVFFRAL------MRDFDAGYSDTAWVSSIMLA 66

  Fly   134 TTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPT 198
            ..:....::..|..:.|.|....|||:|::.|::|:||.|..: .||.|.|::.|||.||.:.|:
Human    67 MLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLL-ELYLTAGVLTGLGLALNFQPS 130

  Fly   199 LAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYK 263
            |.:||.||:|.....:|...|||.||...|.|...:||..:|..|.   ..|:...::.|.....
Human   131 LIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGG---FLLLGGLLLHCCACGA 192

  Fly   264 PLHPPPEP---PKK---------KPGRSRIN---LFLRS----------IINVEIWKRKRFVIWA 303
            .:.|||.|   |::         .||.:..:   |.||.          ::::.:...:.|.::|
Human   193 VMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYA 257

  Fly   304 LCVPLALFGYFVPYVHMMQFVKTT-FPGEDVNLPVMCIGITSGIGRLIFGVIADMPGVNRM---- 363
            :...|...|.|||.:.::.:.|.. .|..|....:..:|....:.|...|.:|   |:.|:
Human   258 VTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALA---GLARLRPHV 319

  Fly   364 -YLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEI----CGPSGATQA 423
             ||..|:|::.||..|......||..||:|.:..||..|    ::|.:.:|:    .|......|
Human   320 PYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYG----MVGALQFEVLMAAVGAPRFPSA 380

  Fly   424 IGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFL-----IKCVK------ 477
            :|.:|.:.:..:.:|||.||.:.|...:|.:...|||....|....:.:     ::|.|
Human   381 LGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGP 445

  Fly   478 -----------EEENGVSAPRAVVLAN-GDIE 497
                       .|..|.|.|..||... |::|
Human   446 GTEGGASDTEDAEAEGDSEPLPVVAEEPGNLE 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	108/413 (26%)
		MFS_1	124..439	CDD:284993	90/349 (26%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	121/468 (26%)
		MFS	19..429	CDD:119392	112/426 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..224		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..504		8/37 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920