DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and Slc16a4

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_666248.1	Gene:	Slc16a4 / 229699	MGIID:	2385183	Length:	500	Species:	Mus musculus

Alignment Length:	479	Identity:	110/479 - (22%)
Similarity:	201/479 - (41%)	Gaps:	87/479 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 EPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTF 136
            :|.||| ..|:|::..||.|..:.|...|:.:...:..:..     ...|.:...||::.....|
Mouse    13 KPLDGG-WGWMVVLHFFLVNVFVMGMTKTFAIFFVVFQEEF-----EGTSEQIGWIGSIMSSLRF 71

  Fly   137 LFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAI 201
            ....:|..:.|.:|.:.|:..|..|.:||.::||:.| .|..|..|.|::.|||:|..|.....:
Mouse    72 SAGPLAAIICDVLGEKATSILGTFLVSGGYVISSWAT-GIPFLCVTMGLLPGLGSAFLYQVAAVV 135

  Fly   202 LGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLH 266
            :..|||:.||..:....:|..: |.:|.|....|:..|...|.|.:...:...::..|.:.:|:|
Mouse   136 ITKYFKKRLGLSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIILNLVPSSMLLRPIH 199

  Fly   267 ------------------PPPE------------------------------------------- 270
                              ..||
Mouse   200 SQSNNNSDIENKGSILSATEPEASYKTETSKCKETQEPFIKDSTMKKSEQPTTTLTVLGNQSEEF 264

  Fly   271 ---PPKKKP-----GRSRINLFL-----RSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQ 322
               |.:.:|     |:|....|:     :.::::.:::...|.|:.....|:...||:|..|::.
Mouse   265 SNRPHRNRPLLMSNGKSHKKKFVSWNCKQKLLDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVA 329

  Fly   323 FVKTTFPGEDV---NLPVMCIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLLLPLTN 384
            ..||.  |.||   :..|...|||..:.:||.|.|||...:.:....:..|:..|:..||.||..
Mouse   330 RAKTL--GIDVMDASYLVSVAGITETVSQLISGWIADQNWIKKYQYHKSYLILCGVTNLLAPLAT 392

  Fly   385 SYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDST 449
            ::.:|:::|::..:|.|.:::|:.|:..::...|...:.:|:....:.|.:..|||:||.|:|.|
Mouse   393 TFPLLMAYTILFAIFAGGYLALILPVLVDLSKNSRVHKFLGYASFFAGIAVLSGPPIAGWIYDYT 457

  Fly   450 NSYTLPLILAGLPPLLGSSLLFLI 473
            .:||.....:|...:|.|..||.:
Mouse   458 QTYTGSFYFSGTCYILSSVSLFFV 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	101/454 (22%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	83/391 (21%)
Slc16a4	NP_666248.1	2A0113	7..479	CDD:273325	108/475 (23%)
Slc16a4	NP_666248.1	MFS	24..482	CDD:119392	104/467 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820