DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kar and Slc16a10

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_620186.1	Gene:	Slc16a10 / 170566	RGDID:	69197	Length:	514	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	208/497 - (41%)
Similarity:	292/497 - (58%)	Gaps:	44/497 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PVQNGNGNANGT--HIEAPCCRDIHGKEPPD--GGARAWLVMVSAFLCNGIIFGFINTYGVIHSL 107
            ||...:..::|:  .:|....|....:|||:  .|...||||::|..|||.:||..|.|||:...
  Rat    32 PVPGPSDVSDGSVEKVEVELTRSTGNQEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNAYGVLFVS 96

  Fly   108 LTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFC 172
            :.:......|...:.|||.:|:|::|..|....:....||..|.|.|...|..:...||:.|||
  Rat    97 MLETFGAKDDDNMAFKAAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVLGAAVGFVGLMSSSF- 160

  Fly   173 TENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLG 237
            ..:|..||||||::|..|.:.||.|:|.|||||||:.||.|:|.|||||||||::||..|..|..
  Rat   161 VSSIEPLYFTYGVVFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLTS 225

  Fly   238 SYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRSRINLFLR-------SIINVEIWK 295
            :.||..||||:.:....:.|..|.|:||  .|...:|:...||.:.|.|       .|.|..::|
  Rat   226 TVGLCYTLRILCIFMFVLFLAGFTYRPL--VPSSKEKESEDSRSSFFSRRKLSPPKKIFNFALFK 288

  Fly   296 RKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVN---LPVMCIGITSGIGRLIFGVIAD- 356
            ...:.:||..:|||||||||||||:|..||..|  :|||   :..||||:|||:|||:||.|||
  Rat   289 ETAYAVWAAGIPLALFGYFVPYVHLMNHVKERF--KDVNNKEVLFMCIGVTSGVGRLLFGRIADY 351

  Fly   357 MPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGAT 421
            :|||.::|||.||...|||.::::||.:.:..|::..|:||||||||||::.|||:|:.||..|:
  Rat   352 LPGVKKVYLQVLSFFFIGLTSMMIPLCSVFGALIALCLIMGLFDGCFISIMAPIAFELVGPQDAS 416

  Fly   422 QAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVKEEENGVSAP 486
            ||||||||..|||:||||||||::.|...||.|...|||:||.:|.::|.||..:..::..
  Rat   417 QAIGFLLGFMSIPMTVGPPVAGLLHDKLGSYDLAFYLAGIPPFIGGAVLCLIPWIHSKKQR---- 477

  Fly   487 RAVVLANGDIEIAGNGHYRSAGTK------SSAPLMGATNGI 522
                      ||:.|    :.|.|      :.:.|:.:::||
  Rat   478 ----------EISKN----TGGEKMEKMLANQSSLLSSSSGI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	182/388 (47%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	156/325 (48%)
Slc16a10	NP_620186.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		8/31 (26%)
		2A0113	60..481	CDD:273325	196/439 (45%)
		MFS	70..469	CDD:119392	190/403 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3259
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75089
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2086
OMA	1	1.010	-	-		QHG50069
OrthoDB	1	1.010	-	-		D335911at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm44988
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2858
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840