Protein Alignment kar and SLC16A11

DIOPT Version :10

• Sequence 1: NP_001189213.1
• Gene: kar / 45883
• FlyBaseID: FBgn0001296
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_699188.2
• Gene: SLC16A11 / 162515
• HGNCID: 23093
• Length: 447
• Species: Homo sapiens
• Alignment Length: 444
• Identity: 125/444 - (28%)
• Similarity: 206/444 - (46%)
• Gaps: 36/444 - (8%)

  Fly    73 PPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFL 137
            ||||| ..|:|..:||..||:.:|.:.:.|:....|.:...:     ::...|.|.|||:.....
Human     8 PPDGG-WGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDR-----SAQDTAWISALALAVQQA 66

  Fly   138 FSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAIL 202
            .|.:...|:.:.|.|.....||||::.|.:.|:|.::.: .||...|::.|.|.||.:.|.|..|
Human    67 ASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLL-HLYLGLGLLAGFGWALVFAPALGTL 130

  Fly   203 GHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHP 267
            ..||.|......|....|:...:::|.|.|..||.::|..|.|.::..::..:..|..:..||..
Human   131 SRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVL 195

  Fly   268 PPEPPKKKPGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMM-QFVKTTFPGE 331
            |.:||  .|.||.:     :.:.:.::.|:.|.|:||...|...||||||||:. ..:.....|.
Human   196 PGDPP--APPRSPL-----AALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253

  Fly   332 DVNLPVMCIGITSGIGRLIFGVIAD-----MPGVNRMY--LQQLSLVSIGLVTLLLPLTNSYVIL 389
            ...|.|....:.....||:.|.:||     :|.:..::  |..|.|..:|||.::....:....|
Human   254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPL 318

  Fly   390 VSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTL 454
            ::..:..||..|.:..|:..:...:.|..|..||.|.::.|.|:...:|||::|.:.|.|..:|.
Human   319 LAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTA 383

  Fly   455 PLILAGLPPLLGSSLLF-----LIKC-------VKEEENG--VSAPRAVVLANG 494
            ..:|:|...|.||.:..     |..|       ....|.|  :.||:||:|:.|
Human   384 SFLLSGSLILSGSFIYIGLPRALPSCGPASPPATPPPETGELLPAPQAVLLSPG 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS_MCT8_10	80..474	CDD:340978	111/406 (27%)
SLC16A11	NP_699188.2	MFS	14..403	CDD:475125	110/401 (27%)