DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and SLC16A10

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_061063.2	Gene:	SLC16A10 / 117247	HGNCID:	17027	Length:	515	Species:	Homo sapiens

Alignment Length:	470	Identity:	196/470 - (41%)
Similarity:	273/470 - (58%)	Gaps:	29/470 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ANGKDAMKPSAPVQNGNGNANG---------------THIEAPCCRDIH-GKEPPDGGARAWLVM 84
            |.|....:|..|...|.....|               ..:..|...:.| ..|||:|| ..||||
Human    11 ARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHEPPEPPEGG-WGWLVM 74

  Fly    85 VSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKI 149
            ::|..|||.:||..|..||:...:.:......|.:...|.|.:|:|::|..|....:....||..
Human    75 LAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLF 139

  Fly   150 GLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVS 214
            |.|.|...|..:...||:.||| ..:|..||.||||:|..|.:.||.|:|.|||||||:.||.|:
Human   140 GCRKTAVVGAAVGFVGLMSSSF-VSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVN 203

  Fly   215 GFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPPEPPKKKPGRS 279
            |.|||||||||::||..|..|:.|.||..|||::.:....:.|..|.|:||  ......|:.|.|
Human   204 GIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPL--ATSTKDKESGGS 266

  Fly   280 RINLFLR-------SIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGE-DVNLP 336
            ..:||.|       .|.|..|:|...:.:||:.:|||||||||||||:|:.|...|..| :..:.
Human   267 GSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVV 331

  Fly   337 VMCIGITSGIGRLIFGVIAD-MPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFD 400
            :||||:|||:|||:||.||| :|||.::|||.||...|||:::::||.:.:..|::..|:|||||
Human   332 LMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFD 396

  Fly   401 GCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLL 465
            |||||::.|||:|:.|....:||||||||..|||:|||||:||::.|...||.:...|||:|||:
Human   397 GCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLI 461

  Fly   466 GSSLLFLIKCVKEEE 480
            |.::|..|..:..::
Human   462 GGAVLCFIPWIHSKK 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	174/386 (45%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	151/323 (47%)
SLC16A10	NP_061063.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		6/36 (17%)
		2A0113	67..487	CDD:273325	185/414 (45%)
		MFS	71..470	CDD:119392	182/401 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2601
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75089
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2277
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50069
OrthoDB	1	1.010	-	-		D335911at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm40847
orthoMCL	1	0.900	-	-		OOG6_100246
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5423
SonicParanoid	1	1.000	-	-		X2858
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870