DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kar and slc16a6

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_031750265.1	Gene:	slc16a6 / 100494933	XenbaseID:	XB-GENE-6257787	Length:	522	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	112/539 - (20%)
Similarity:	204/539 - (37%)	Gaps:	111/539 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLF 138
            |||| ..|.|..:.|......:|.|.::||..:.|....     .|::|:.:.|.::.:......
Frog    17 PDGG-WGWAVAGAFFFVEVFTYGVIKSFGVFFNELVGYF-----DESNSRISWIISICVFVMTFT 75

  Fly   139 STMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILG 203
            :.::..|:::.|.|.....||:|.:.|::.:|| ..::|.:|...|::.|||..|.:.||:.||.
Frog    76 APLSTVLSNRFGHRPVVMVGGLLISTGMMAASF-ARSVGEMYVAIGLISGLGYCLTFLPTVTILS 139

  Fly   204 HYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSFVYKP--LH 266
            .||:|....|:...:.|.........|.:..|....|....|.::..:...|::|..:.:|  :.
Frog   140 QYFERRRSLVTAVASTGECFAVFAFAPAITALNDLIGWRCCLLMVGALQLNIVVCGSLLRPITIK 204

  Fly   267 PP----------------------------------------------------PEPPKKK---- 275
            ||                                                    ||||:::
Frog   205 PPDVAKSPAKGEALESAYMLENEQTLTSIDSIDSGVEVSTSPKNLPTGLKPARSPEPPRERKETA 269

  Fly   276 ----PGRSRINLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVNL- 335
                |         ..:::..:.:...|:.:||....|..|:|.|.::::....:.  |.|..|
Frog   270 ERPEP---------EPLLDFSVLRNPSFICYALFGLFATLGFFAPSLYIIPLSLSL--GIDRELS 323

  Fly   336 PVM--CIGITSGIGRLIFGVIADMPGVNRMYLQQLSLVSIGLVTLL-LPLTNSY----VILVSFT 393
            |.|  .:.|:...||:..|.|.:...|.::|: :|:.|::..|.|| .|...::    ...|.|.
Frog   324 PYMLSAMAISEVFGRIGAGWILNKKPVRKIYI-ELAFVALLCVALLAFPFAWNFGGLMACSVFFG 387

  Fly   394 LVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLIL 458
            .::|...|..|.|:.  ..:|.|.......:|..:.:.|:....|||:.|::.|.|.:|......
Frog   388 GMLGTVTGTHIPLVA--EDDIVGIDKMASGVGVYVFIQSVAGLAGPPLGGVLVDWTQNYGSAFYS 450

  Fly   459 AGLPPLLGSSLLFLIKCVKEEENGVSAPRAVVLANGDIEIAGNGHYRSAGTKSSAPL------MG 517
            ......||:..|.|::..| ...|...|.|             ||:.........|:      :.
Frog   451 CAAGMALGALFLALVRPCK-RGLGKEKPAA-------------GHHPLCQDAKELPVDFLEMDLA 501

  Fly   518 ATNGINGSAPASPTIQSNG 536
            ...|::.|..:.....|||
Frog   502 RAEGLSKSCQSLNEAPSNG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	92/447 (21%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	75/384 (20%)
slc16a6	XP_031750265.1	MFS_MCT7	22..466	CDD:340980	96/463 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010