DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kar and slc16a2

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_031747020.1	Gene:	slc16a2 / 100494635	XenbaseID:	XB-GENE-980579	Length:	499	Species:	Xenopus tropicalis

Alignment Length:	478	Identity:	188/478 - (39%)
Similarity:	287/478 - (60%)	Gaps:	29/478 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KDAMKPSAPVQNGNGNANGTHIEAPCCRDIHGK-EPPDGGARAWLVMVSAFLCNGIIFGFINTYG 102
            :|::...||    .|.|....:..|..|:..|: ..|:||. .|:|:::|..|:|.|||..|::|
Frog    20 RDSLLGGAP----EGAAVPAEVPVPGKREEDGRGRVPEGGF-GWVVVLAATWCSGSIFGIQNSFG 79

  Fly   103 VIHSLLTDRLTKLGDPEASSKAALIGALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLL 167
            :|:.:|...:....:.....|.|.:|:||:|..|..|.:....||::|.|.|:..|..|:..|||
Frog    80 IIYVMLQGEMDGTEEQGMDFKTAWVGSLAMGMIFFCSPVVSIFTDRLGCRKTSSGGAALAFIGLL 144

  Fly   168 LSSFCTENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCL 232
            .||| |:::|..||||||:||.|.:.|:.|:|.|||||||:.||.|:|.|..||.|||:.||..|
Frog   145 SSSF-TKSLGVRYFTYGILFGCGCSFAFQPSLVILGHYFKKRLGLVNGIVAGGSCVFTMCLPFLL 208

  Fly   233 DKLLGSYGLEGTLRIMSLVSAFIILCSFVYKPLHPPP----EPPKKKPGRSRINLFL---RSIIN 290
            ..:.|:.||:.|.:::|:.....|..|..:|||.|||    :..:|..|||:....:   |...|
Frog   209 KMMGGAIGLQHTFQVLSVFMFIQIFLSLTFKPLLPPPVDFSKEKEKVAGRSKAQQCMAHTRKYFN 273

  Fly   291 VEIWKRKRFVIWALCVPLALFGYFVPYVHMMQFVKTTFPGEDVN--LPVMCIGITSGIGRLIFGV 353
            :::::||.:.||||.:...:.||||||||:::||:..|. |:..  :.::|||.|||||||..|.
Frog   274 MQVFRRKTYTIWALGIATTVLGYFVPYVHLIKFVEQRFK-ENTKEWVLLVCIGATSGIGRLASGR 337

  Fly   354 IAD-MPGVNRMYLQQLSLVSIGLVTLLLPLTNSYVILVSFTLVMGLFDGCFISLLGPIAYEICGP 417
            |.| :||:.::|||..|.:.:|:::::|||...:..::...|.:||.||..||::.|||:|:.||
Frog   338 IGDSIPGLKKIYLQVASFLLLGILSMMLPLCQVFESVIVVCLFLGLCDGFLISMMSPIAFELVGP 402

  Fly   418 SGATQAIGFLLGLSSIPLTVGPPVAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIKCVKE---- 478
            ..|:||||::|||.|||:|.|||:||::.|...||.|...|||:|||:|:.:|..:..|.|
Frog   403 MQASQAIGYVLGLMSIPMTAGPPIAGLLRDYCGSYDLAFYLAGIPPLIGAMVLLSVPLVHERDLK 467

  Fly   479 -----EENGVSAPRAVVLANGDI 496
                 ||.......:||  ||::
Frog   468 KKRQMEEEKEKTQDSVV--NGEL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	161/387 (42%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	139/324 (43%)
slc16a2	XP_031747020.1	MFS_MCT8	57..459	CDD:341023	169/403 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2605
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2223
OMA	1	1.010	-	-		QHG50069
OrthoDB	1	1.010	-	-		D335911at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm48045
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2858
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080