DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kar and slc16a10

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_012819019.1	Gene:	slc16a10 / 100488837	XenbaseID:	XB-GENE-1012623	Length:	516	Species:	Xenopus tropicalis

Alignment Length:	504	Identity:	207/504 - (41%)
Similarity:	290/504 - (57%)	Gaps:	44/504 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENEPLNDLQSQVNGRILPAANGHTASATNGLVHANGKDAMKPSAPVQNGNGNANGTHIEAPCCRD 67
            |..|||.::.:.||.:.|      .|.....:.||  |...|.|..::.
Frog    21 EMSPLNSVEGKENGEMDP------VSIEEEKLKAN--DEKDPEAAKESA---------------- 61

  Fly    68 IHGKE--PPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALIGAL 130
            :..||  ||:|| ..|:|||:|..|||.:||..|..||:...|.:......|.|.:.|.|.:.:|
Frog    62 LEDKEFQPPEGG-WGWMVMVAAMWCNGSVFGIQNACGVLFVSLIEEFGSKDDTEMTFKTAWVNSL 125

  Fly   131 AIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAALAY 195
            ::|..|..|.:....||..|.|.|...|..:...|||.||| ..::..|||||||:|..|.:.||
Frog   126 SMGMIFFCSPVVSIFTDIFGCRKTATVGAAVGIVGLLSSSF-VSSLEPLYFTYGILFACGCSFAY 189

  Fly   196 TPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIILCSF 260
            .|:|.|||||||:.||.|:|.||||||:|||.||..|..||....|..||:::.::...:.|..|
Frog   190 QPSLVILGHYFKKRLGLVNGIVTAGSSLFTVSLPFVLRFLLDKIRLFKTLQVLCILMFILFLAGF 254

  Fly   261 VYKPLHPPPEPPK-KKPGRSR---INLFLRSIINVEIWKRKRFVIWALCVPLALFGYFVPYVHMM 321
            .||||.|.....: ||.|:.|   :|    .:.|..|:|.:.:.:||..:|.|||||||||||:|
Frog   255 TYKPLVPRRSNLEFKKNGKFRCPSVN----KLFNFSIFKSRSYCLWAFGIPAALFGYFVPYVHLM 315

  Fly   322 QFVKTTFPGEDVNLPV--MCIGITSGIGRLIFGVIAD-MPGVNRMYLQQLSLVSIGLVTLLLPLT 383
            ..|:... ||||...|  :|||:|||:||||||.:|| :|||.::|||.:|...|||:::::||.
Frog   316 NHVRERL-GEDVKEEVLLLCIGVTSGVGRLIFGRVADYIPGVKKVYLQVVSFFFIGLMSMMIPLC 379

  Fly   384 NSYVILVSFTLVMGLFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPPVAGMIFDS 448
            :::..|::..|.|||||||||.::.|||:|:.||...:||||||||..|||:|||||:||::.|.
Frog   380 HNFGGLIAVCLFMGLFDGCFICIMAPIAFELVGPENVSQAIGFLLGFMSIPMTVGPPIAGILHDR 444

  Fly   449 TNSYTLPLILAGLPPLLGSSLLFLIKCVKEEENGVSAPRAVVLANGDIE 497
            ..||.:...|||:||::|..:|.||..:.:.    :..:..:..|||.|
Frog   445 LGSYDVAFYLAGIPPIIGGIILCLIPWIHQR----TLQKKTIAVNGDAE 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	175/384 (46%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	150/321 (47%)
slc16a10	XP_012819019.1	MFS_MCT10	75..455	CDD:341022	175/385 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2605
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75089
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2223
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335911at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm48045
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2858
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060