DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kar and slc16a13

DIOPT Version :9

Sequence 1:	NP_001189213.1	Gene:	kar / 45883	FlyBaseID:	FBgn0001296	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001090862.1	Gene:	slc16a13 / 100038279	XenbaseID:	XB-GENE-5905916	Length:	516	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	142/543 - (26%)
Similarity:	233/543 - (42%)	Gaps:	78/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PCCRDIHGKEPPDGGARAWLVMVSAFLCNGIIFGFINTYGVIHSLLTDRLTKLGDPEASSKAALI 127
            ||      ..|..|..|..::::|.|:..|::||.:.:.||......:..     ..|:...:.:
Frog     2 PC------SLPRQGDIRGAVLLLSCFMQAGLVFGTVRSLGVFFPAFVENF-----ESAAGSVSWV 55

  Fly   128 GALAIGTTFLFSTMAGCLTDKIGLRLTTFAGGVLSAGGLLLSSFCTENIGALYFTYGIMFGLGAA 192
            .:..:....|.|.:...|..:.|.|.....||:|||.|:..:||.|| :..||...|.:.|||.|
Frog    56 TSCGVAVQQLLSPLGCSLALRFGSRPVVILGGLLSALGMFFASFATE-LYQLYLCIGGLSGLGWA 119

  Fly   193 LAYTPTLAILGHYFKRYLGKVSGFVTAGSSVFTVILPPCLDKLLGSYGLEGTLRIMSLVSAFIIL 257
            :.::||:|.:..||||.....:|||..|..||:..|.|.|..||.:|...|.|.::|.::...:.
Frog   120 MIFSPTMAAVTCYFKRRRSLATGFVLMGVGVFSFALSPLLQYLLETYSWRGALLLLSGLALHSVP 184

  Fly   258 CSFVYKPLHP--PPEPPKKKPGRSRINLFLRSIINVEIWK---RKRFVIWALCVPLALFGYFVPY 317
            |..:.:|.:|  |.||...         ||..      ||   ...|:.:.|.:.....||||||
Frog   185 CGALLRPRNPTEPQEPSYP---------FLWG------WKLLGEGVFLRYCLAITSINTGYFVPY 234

  Fly   318 VHMMQFVKTTFPGE-DVNLPVMCIGITSGIGRLIFGVIADM-PGVNRMYLQQLSLVSIGLVTLLL 380
            ||::..::....|| ...:.:..:|:....|||..|.::|: |....|:|...:.:| |::..||
Frog   235 VHLVAHMRAQGAGEWHAAMVMSVVGVADVGGRLFAGWLSDLAPRHTLMFLSLWTGLS-GVILGLL 298

  Fly   381 PLTNSYVIL----VSFTLVMG-LFDGCFISLLGPIAYEICGPSGATQAIGFLLGLSSIPLTVGPP 440
            ||....|.:    |:|....| |..|.|.:|.|     :.|......|:|.|..:.|....:|.|
Frog   299 PLATKVVEMGAAAVAFGFCAGALTPGVFSALPG-----VVGDQRVLPALGLLQMIESGGGLLGAP 358

  Fly   441 VAGMIFDSTNSYTLPLILAGLPPLLGSSLLFLIK---CVKEEENGVSAPRAVVLANGDIEIAGNG 502
            ::|.:.|.|..:|....:||...:||:.:|..:.   |.|:....::..   ...:.|.:.:...
Frog   359 ISGWLCDLTGDFTASFAVAGSFLILGALILLTVPRVFCTKQTNPSLNNK---AFTSWDGQSSSRE 420

  Fly   503 HYR------SAG--TKSSAPLMGA------TNG-INGSAPASPTIQSNGHVDNGTG----SYPDS 548
            |.:      |.|  ||..:.::..      |.| ::||...|       .:.||||    .....
Frog   421 HKKPPVKNISQGRSTKDQSFIITTDQSQIRTEGELSGSTDQS-------ELKNGTGLPLYETNGQ 478

  Fly   549 PW-PSPTRISDSAACDHSSSSLH 570
            || .||..:..|...:|::...:
Frog   479 PWSSSPKSLFRSTWTNHNNGDAY 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kar	NP_001189213.1	MFS	81..459	CDD:119392	109/389 (28%)
kar	NP_001189213.1	MFS_1	124..439	CDD:284993	95/326 (29%)
slc16a13	NP_001090862.1	MFS_MCT11_13	13..392	CDD:340981	114/405 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010