Protein Alignment Ldh and MDH2

DIOPT Version :9

• Sequence 1: NP_001261474.1
• Gene: Ldh / 45880
• FlyBaseID: FBgn0001258
• Length: 332
• Species: Drosophila melanogaster
• Sequence 2: NP_005909.2
• Gene: MDH2 / 4191
• HGNCID: 6971
• Length: 338
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 75/320 - (23%)
• Similarity: 134/320 - (41%)
• Gaps: 74/320 - (23%)

  Fly    10 AQVAEVLPSSGHKVTIVGIGQVGMASAFSILAQN---VSKEVCLIDVCADKLQGELMDLQH---- 67
            |:|| ||.:||      ||||     ..|:|.:|   ||: :.|.|:.  ...|...||.|
Human    25 AKVA-VLGASG------GIGQ-----PLSLLLKNSPLVSR-LTLYDIA--HTPGVAADLSHIETK 74

  Fly    68 -------GSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLV 125
                   |...|  |......|        :.::.|||.:|.|.:|..|...|..|:..:.....
Human    75 AAVKGYLGPEQL--PDCLKGCD--------VVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACA 129

  Fly   126 EYSPDTILLMVSNPVDI---MTYVAWKLSGL-PKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCH 186
            ::.|:.::.:::|||:.   :|...:|..|: ..|::.|. |.||..|....:::..|:.|...:
Human   130 QHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGV-TTLDIVRANTFVAELKGLDPARVN 193

  Fly   187 GWIIGEH-GDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSW 250
            ..:||.| |.:.:|:          :.:..|.:...:|  :...|..::.::..||:|.|.
Human   194 VPVIGGHAGKTIIPL----------ISQCTPKVDFPQD--QLTALTGRIQEAGTEVVKAKA---- 242

  Fly   251 AIGLSTASLASAILRNTSSVAAVSTSVLGEHGI----------DKDVFLSLPCVLNANGV 300
            ..|.:|.|:|.|..|   .|.::..::.|:.|:          .:..:.|.|.:|...|:
Human   243 GAGSATLSMAYAGAR---FVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGI 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_001261474.1	LDH_1	18..329	CDD:133429	70/312 (22%)
MDH2	NP_005909.2	MDH_glyoxysomal_mitochondrial	26..334	CDD:133422	74/319 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810