DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ldh and MDH1

DIOPT Version :9

Sequence 1:	NP_001261474.1	Gene:	Ldh / 45880	FlyBaseID:	FBgn0001258	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_001303303.1	Gene:	MDH1 / 4190	HGNCID:	6970	Length:	353	Species:	Homo sapiens

Alignment Length:	332	Identity:	82/332 - (24%)
Similarity:	137/332 - (41%)	Gaps:	43/332 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KVTIVG-IGQVGMASAFSILAQNV-SKEVCLIDVCAD------KLQGELMDLQHGSNFLKNPQIT 78
            :|.:.| .||:..:..:||...:| .|:..:|.|..|      .|.|.||:||..:..|....|.
Human     6 RVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIA 70

  Fly    79 ASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEYSPDTI-LLMVSNPVDI 142
            ...:..|..:..:.|:...:.::||..|..|::.|..|.|:....|.:|:..:: :::|.||.:.
Human    71 TDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANT 135

  Fly   143 MTYVAWKLS-GLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWII-GEHGDSSVPVWSGVN 205
            ....|.|.: .:||.. ....|.||.:|.:..::.:|||........|| |.|..:..|   .||
Human   136 NCLTASKSAPSIPKEN-FSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYP---DVN 196

  Fly   206 IAGVRL--RELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSWAIGLSTASLASAILRNTS 268
            .|.|:|  :|:.......:|.....|....|......|||.:..:      |..|.|.||..:..
Human   197 HAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLS------SAMSAAKAICDHVR 255

  Fly   269 SV-------AAVSTSVLGE---HGIDKDVFLSLPCVLN------ANGVT----SVVKQILTPTEV 313
            .:       ..||..|:.:   :|:..|:..|.|.|:.      ..|:.    |..|..||..|:
Human   256 DIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKEL 320

  Fly   314 EQLQKSA 320
            .:.::||
Human   321 TEEKESA 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_001261474.1	LDH_1	18..329	CDD:133429	82/332 (25%)
MDH1	NP_001303303.1	MalateDH-SF1	2..327	CDD:130820	80/330 (24%)
		MDH_cytoplasmic_cytosolic	3..328	CDD:133421	82/332 (25%)
		PTS1	351..353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810