DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ldh and LDHB

DIOPT Version :9

Sequence 1:	NP_001261474.1	Gene:	Ldh / 45880	FlyBaseID:	FBgn0001258	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	XP_006719137.1	Gene:	LDHB / 3945	HGNCID:	6541	Length:	353	Species:	Homo sapiens

Alignment Length:	280	Identity:	177/280 - (63%)
Similarity:	232/280 - (82%)	Gaps:	5/280 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAIKDSLLAQVAE---VLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGEL 62
            ||.:|:.|:|.|||   .:|:  :|:|:||:||||||.|.|||.::::.|:.|:||..|||:||:
Human     1 MATLKEKLIAPVAEEEATVPN--NKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEM 63

  Fly    63 MDLQHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEY 127
            |||||||.||:.|:|.|..|::.:|||::.:|||||||:||||||:|||||.::.|.|||::|:|
Human    64 MDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKY 128

  Fly   128 SPDTILLMVSNPVDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWIIGE 192
            |||.|:::|||||||:|||.||||||||:||||||.||||:|||:||:::||:.|:||||||:||
Human   129 SPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGE 193

  Fly   193 HGDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSWAIGLSTA 257
            ||||||.||||||:|||.|:||||.:||..|.|.|.|:||.||:||||||||||||:||||||.|
Human   194 HGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVA 258

  Fly   258 SLASAILRNTSSVAAVSTSV 277
            .|..::|:|.|.:..|||.|
Human   259 DLIESMLKNLSRIHPVSTMV 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_001261474.1	LDH_1	18..329	CDD:133429	168/260 (65%)
LDHB	XP_006719137.1	LDH_1	20..279	CDD:133429	169/261 (65%)
LDHB	XP_006719137.1	L-LDH-NAD	26..279	CDD:273796	166/253 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2593
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1739
Isobase	1	0.950	-	0	Normalized mean entropy	S1577
OMA	1	1.010	-	-		QHG59943
OrthoDB	1	1.010	-	-		D1204514at2759
OrthoFinder	1	1.000	-	-		FOG0001004
OrthoInspector	1	1.000	-	-		otm40444
orthoMCL	1	0.900	-	-		OOG6_100601
Panther	1	1.100	-	-	LDO	PTHR43128
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R655
SonicParanoid	1	1.000	-	-		X661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820