Protein Alignment Ldh and LDHA

DIOPT Version :9

• Sequence 1: NP_001261474.1
• Gene: Ldh / 45880
• FlyBaseID: FBgn0001258
• Length: 332
• Species: Drosophila melanogaster
• Sequence 2: NP_001158886.1
• Gene: LDHA / 3939
• HGNCID: 6535
• Length: 361
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 199/332 - (59%)
• Similarity: 261/332 - (78%)
• Gaps: 0/332 - (0%)

  Fly     1 MAAIKDSLLAQVAEVLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGELMDL 65
            ||.:||.|:..:.:...:..:|:|:||:|.||||.|.|||.::::.|:.|:||..|||:||:|||
Human    30 MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDL 94

  Fly    66 QHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEYSPD 130
            ||||.||:.|:|.:..|:..:|||:|.|:|||.||:||||||:|||||.:|.|.|||.:|:|||:
Human    95 QHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPN 159

  Fly   131 TILLMVSNPVDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWIIGEHGD 195
            ..||:|||||||:||||||:||.|||||||||.||||:|||:||.:||||.|.|||||::|||||
Human   160 CKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGD 224

  Fly   196 SSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSWAIGLSTASLA 260
            ||||||||:|:|||.|:.|:|.|||.:|.|:|.|:|||||:|||||||||||||||||||.|.||
Human   225 SSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLA 289

  Fly   261 SAILRNTSSVAAVSTSVLGEHGIDKDVFLSLPCVLNANGVTSVVKQILTPTEVEQLQKSANIMSD 325
            .:|::|...|..|||.:.|.:||..|||||:||:|..||::.:||..||..|..:|:|||:.:..
Human   290 ESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWG 354

  Fly   326 VQAGLKF 332
            :|..|:|
Human   355 IQKELQF 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_001261474.1	LDH_1	18..329	CDD:133429	192/310 (62%)
LDHA	NP_001158886.1	LDH_1	48..358	CDD:133429	192/309 (62%)
		L-LDH-NAD	54..353	CDD:273796	189/298 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2593
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56495
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1739
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59943
OrthoDB	1	1.010	-	-		D1204514at2759
OrthoFinder	1	1.000	-	-		FOG0001004
OrthoInspector	1	1.000	-	-		otm40444
orthoMCL	1	0.900	-	-		OOG6_100601
Panther	1	1.100	-	-	O	PTHR43128
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R655
SonicParanoid	1	1.000	-	-		X661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870