DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ldh and ldhba

DIOPT Version :9

Sequence 1:	NP_001261474.1	Gene:	Ldh / 45880	FlyBaseID:	FBgn0001258	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_571322.1	Gene:	ldhba / 30497	ZFINID:	ZDB-GENE-991026-6	Length:	334	Species:	Danio rerio

Alignment Length:	337	Identity:	195/337 - (57%)
Similarity:	264/337 - (78%)	Gaps:	11/337 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAIKDSLLAQVAEVLPSSG------HKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQ 59
            ||::...|:..:|     ||      :||||||:||||||.|.|:|.:.::.|:.|:||..|:|:
Zfish     1 MASVMQKLITPLA-----SGPAEPPRNKVTIVGVGQVGMACAVSVLLRELADELALVDVVEDRLK 60

  Fly    60 GELMDLQHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKL 124
            ||::||||||.|||.|:|.|..|::.:||||:.:|||||||:||||||:|||||.:|.|:|||::
Zfish    61 GEMLDLQHGSLFLKTPKIVADKDYSVTANSRIVVVTAGVRQQEGESRLNLVQRNVNIFKHIIPQI 125

  Fly   125 VEYSPDTILLMVSNPVDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWI 189
            |:||||.||::||||||::|||.||||||||:||||||.||||:|||::|:::||:..:|.:|:|
Zfish   126 VKYSPDCILVVVSNPVDVLTYVTWKLSGLPKHRVIGSGPNLDSARFRYIMAEKLGIHASSFNGYI 190

  Fly   190 IGEHGDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVIKLKGYTSWAIGL 254
            :|||||:|||||||.|:|||.|::|||.:||.:|.|.|.|.||.|||||||||||||||:|||||
Zfish   191 LGEHGDTSVPVWSGANVAGVSLQKLNPDIGTDKDAENWKEAHKMVVDSAYEVIKLKGYTNWAIGL 255

  Fly   255 STASLASAILRNTSSVAAVSTSVLGEHGIDKDVFLSLPCVLNANGVTSVVKQILTPTEVEQLQKS 319
            |.|.|...:::|.:.|..|||.|.|.:||:::|:||||||||::||.||:...||..|:.||:.|
Zfish   256 SVADLTETLVKNLNRVHPVSTMVKGMYGINEEVYLSLPCVLNSSGVGSVINMTLTDGEIGQLKSS 320

  Fly   320 ANIMSDVQAGLK 331
            |:.:..:|..||
Zfish   321 ADTLWGIQKDLK 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_001261474.1	LDH_1	18..329	CDD:133429	189/316 (60%)
ldhba	NP_571322.1	PLN02602	4..332	CDD:178212	191/332 (58%)
ldhba	NP_571322.1	LDH_1	19..330	CDD:133429	187/310 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2591
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1801
OMA	1	1.010	-	-		QHG59943
OrthoDB	1	1.010	-	-		D1204514at2759
OrthoFinder	1	1.000	-	-		FOG0001004
OrthoInspector	1	1.000	-	-		otm26445
orthoMCL	1	0.900	-	-		OOG6_100601
Panther	1	1.100	-	-	LDO	PTHR43128
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R655
SonicParanoid	1	1.000	-	-		X661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870