DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ldh and ldh-1

DIOPT Version :9

Sequence 1:	NP_001261474.1	Gene:	Ldh / 45880	FlyBaseID:	FBgn0001258	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_001343759.1	Gene:	ldh-1 / 174798	WormBaseID:	WBGene00002262	Length:	336	Species:	Caenorhabditis elegans

Alignment Length:	331	Identity:	204/331 - (61%)
Similarity:	263/331 - (79%)	Gaps:	1/331 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAIKDSLLAQVAEVLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGELMDL 65
            ||:....:.|::|..:.:|..|||:||:||||||.|:|||.||::.|:||:||.||||:||:|||
Worm     4 MASTIKEVFAEIAAPVENSHGKVTVVGVGQVGMACAYSILQQNLANELCLVDVVADKLKGEMMDL 68

  Fly    66 QHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEYSPD 130
            |||..|.::..:.|.||::.:|.|:||:||||.||:|||:||||||||.:|.|.|||:||:||||
Worm    69 QHGLAFTRHCTVKADTDYSITAGSKLCVVTAGARQREGETRLSLVQRNVEIFKGIIPQLVKYSPD 133

  Fly   131 TILLMVSNPVDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQRLGVAPTSCHGWIIGEHGD 195
            |.:|:||||||::|||.|||||||:.||.||||||||:|||||:|::|.:||:||||||||||||
Worm   134 TCILVVSNPVDVLTYVTWKLSGLPRERVFGSGTNLDSARFRFLLSEKLNIAPSSCHGWIIGEHGD 198

  Fly   196 SSVPVWSGVNIAGVRLRELNPILGTGEDPEKWN-ELHKQVVDSAYEVIKLKGYTSWAIGLSTASL 259
            |||.||||||:|||.|.|:.|.:|...|.|.|. |:||:|||||||:||||||||||||||.|.:
Worm   199 SSVAVWSGVNVAGVTLHEIKPDIGEKTDNEHWEAEIHKKVVDSAYEIIKLKGYTSWAIGLSVAKI 263

  Fly   260 ASAILRNTSSVAAVSTSVLGEHGIDKDVFLSLPCVLNANGVTSVVKQILTPTEVEQLQKSANIMS 324
            |..|..|:.:|.|:||:|.|.|||:.||:||||.||.:.|:|.||||.||..||::|..||..:.
Worm   264 AQGIFSNSRNVFALSTNVKGFHGINDDVYLSLPVVLGSAGLTHVVKQQLTEAEVQKLHNSAKALL 328

  Fly   325 DVQAGL 330
            :||.|:
Worm   329 EVQNGI 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_001261474.1	LDH_1	18..329	CDD:133429	199/311 (64%)
ldh-1	NP_001343759.1	LDH_1	36..333	CDD:133429	189/296 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167150
Domainoid	1	1.000	210	1.000	Domainoid score	I1649
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56495
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1012
Isobase	1	0.950	-	0	Normalized mean entropy	S1577
OMA	1	1.010	-	-		QHG59943
OrthoDB	1	1.010	-	-		D1204514at2759
OrthoFinder	1	1.000	-	-		FOG0001004
OrthoInspector	1	1.000	-	-		oto17784
orthoMCL	1	0.900	-	-		OOG6_100601
Panther	1	1.100	-	-	LDO	PTHR43128
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R655
SonicParanoid	1	1.000	-	-		X661
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790