DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ldh and LDHAL6A

DIOPT Version :9

Sequence 1:	NP_001261474.1	Gene:	Ldh / 45880	FlyBaseID:	FBgn0001258	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	XP_011518224.1	Gene:	LDHAL6A / 160287	HGNCID:	28335	Length:	374	Species:	Homo sapiens

Alignment Length:	349	Identity:	189/349 - (54%)
Similarity:	242/349 - (69%)	Gaps:	18/349 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAIKDSLLAQVAEVLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGELMDL 65
            ||.||..|:...||......:|::|||.|.||:|.|.|||.:.:|.|:.|:||...||:||.|||
Human    25 MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKGETMDL 89

  Fly    66 QHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEYSPD 130
            ||||.|:|.|.|.:|.|:..:|||.|.|:|||.|||:||:||.|||||..|.|.:||.:.:|||.
Human    90 QHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPH 154

  Fly   131 TILLMVSNP------------------VDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQR 177
            ..||:|:||                  |||:|||||||||.|||||||||.||||:|||:.:.||
Human   155 CKLLIVTNPALCMRKLKDISTILLSISVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQR 219

  Fly   178 LGVAPTSCHGWIIGEHGDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVI 242
            ||:...||||.|:|||||||||||||||||||.|::|||.:||.:|||:|..:||:|:.|.||::
Human   220 LGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMV 284

  Fly   243 KLKGYTSWAIGLSTASLASAILRNTSSVAAVSTSVLGEHGIDKDVFLSLPCVLNANGVTSVVKQI 307
            |:||||||.|.||.|.|..:||:|...|..|||...|.:||::|:|||:||:|..||:|.::|..
Human   285 KMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGITDLIKVK 349

  Fly   308 LTPTEVEQLQKSANIMSDVQAGLK 331
            ||..|...|||||..:.::|..||
Human   350 LTLEEEACLQKSAETLWEIQKELK 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_001261474.1	LDH_1	18..329	CDD:133429	180/328 (55%)
LDHAL6A	XP_011518224.1	LDH_1	43..371	CDD:133429	180/327 (55%)
LDHAL6A	XP_011518224.1	L-LDH-NAD	49..367	CDD:273796	178/317 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2593
eggNOG	1	0.900	-	-		E1_COG0039
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1739
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59943
OrthoDB	1	1.010	-	-		D1204514at2759
OrthoFinder	1	1.000	-	-		FOG0001004
OrthoInspector	1	1.000	-	-		otm40444
orthoMCL	1	0.900	-	-		OOG6_100601
Panther	1	1.100	-	-	O	PTHR43128
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R655
SonicParanoid	1	1.000	-	-		X661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870