Protein Alignment Ldh and LDHAL6A

DIOPT Version :10

• Sequence 1: NP_476581.1
• Gene: Ldh / 45880
• FlyBaseID: FBgn0001258
• Length: 332
• Species: Drosophila melanogaster
• Sequence 2: XP_011518224.2
• Gene: LDHAL6A / 160287
• HGNCID: 28335
• Length: 399
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 189/349 - (54%)
• Similarity: 242/349 - (69%)
• Gaps: 18/349 - (5%)

  Fly     1 MAAIKDSLLAQVAEVLPSSGHKVTIVGIGQVGMASAFSILAQNVSKEVCLIDVCADKLQGELMDL 65
            ||.||..|:...||......:|::|||.|.||:|.|.|||.:.:|.|:.|:||...||:||.|||
Human    50 MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKGETMDL 114

  Fly    66 QHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKNIIPKLVEYSPD 130
            ||||.|:|.|.|.:|.|:..:|||.|.|:|||.|||:||:||.|||||..|.|.:||.:.:|||.
Human   115 QHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLMIPNITQYSPH 179

  Fly   131 TILLMVSNP------------------VDIMTYVAWKLSGLPKNRVIGSGTNLDSSRFRFLMSQR 177
            ..||:|:||                  |||:|||||||||.|||||||||.||||:|||:.:.||
Human   180 CKLLIVTNPALCMRKLKDISTILLSISVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQR 244

  Fly   178 LGVAPTSCHGWIIGEHGDSSVPVWSGVNIAGVRLRELNPILGTGEDPEKWNELHKQVVDSAYEVI 242
            ||:...||||.|:|||||||||||||||||||.|::|||.:||.:|||:|..:||:|:.|.||::
Human   245 LGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYEMV 309

  Fly   243 KLKGYTSWAIGLSTASLASAILRNTSSVAAVSTSVLGEHGIDKDVFLSLPCVLNANGVTSVVKQI 307
            |:||||||.|.||.|.|..:||:|...|..|||...|.:||::|:|||:||:|..||:|.::|..
Human   310 KMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGITDLIKVK 374

  Fly   308 LTPTEVEQLQKSANIMSDVQAGLK 331
            ||..|...|||||..:.::|..||
Human   375 LTLEEEACLQKSAETLWEIQKELK 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ldh	NP_476581.1	LDH_1	18..329	CDD:133429	180/328 (55%)
LDHAL6A	XP_011518224.2	LDH_1	68..396	CDD:133429	180/327 (55%)