DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUC6 and Muc6

DIOPT Version :9

Sequence 1:	NP_005952.2	Gene:	MUC6 / 4588	HGNCID:	7517	Length:	2439	Species:	Homo sapiens
Sequence 2:	NP_001355882.2	Gene:	Muc6 / 353328	MGIID:	2663233	Length:	4931	Species:	Mus musculus

Alignment Length:	2696	Identity:	1414/2696 - (52%)
Similarity:	1694/2696 - (62%)	Gaps:	412/2696 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     3 QRWLLLSCCGALLSAGLANTSYTSPGLQRLKDSPQTAPDKGQCSTWGAGHFSTFDHHVYDFSGTC 67
            |..|||...|.|:.||......|....:   |:.|::|:||.|||||||||||||.|.|:|.|.|
Mouse     6 QLLLLLLFRGPLIDAGAWTGDVTDSDTE---DNLQSSPEKGWCSTWGAGHFSTFDGHEYNFQGMC 67

Human    68 NYIFAATCKDAFP-TFSVQLRRGPDGSISRIIVELGASVVTVSEAIISVKDIGVISLPYTSNGLQ 131
            ||||.|||.|..| |||:||||..:|:|||||:|||||||||::..|||:||||:||||||||||
Mouse    68 NYIFTATCGDDVPATFSIQLRRDMEGNISRIIMELGASVVTVNKETISVRDIGVVSLPYTSNGLQ 132

Human   132 ITPFGQSVRLVAKQLELELEVVWGPDSHLMVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLE 196
            |||:||||:||||||||||.:.||||:||.|.||.||||::||||||||||:.|||:||:||.||
Mouse   133 ITPYGQSVQLVAKQLELELVITWGPDAHLTVQVETKYMGKLCGLCGNFDGKIDNEFLSEDGKLLE 197

Human   197 PHKFAALQKLDDPGEICTFQDIPSTHVRQAQHARICTQLLTLVAPECSVSKEPFVLSCQADVAAA 261
            .||:|.|||||||.|||..:.||||.:.:.::|:||.||||||:|.|.|.||..:||||||:||.
Mouse   198 AHKYATLQKLDDPNEICAHEAIPSTIILKTRYAQICNQLLTLVSPGCDVPKETLMLSCQADMAAC 262

Human   262 PQPGPQNSSCATLSEYSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSACVKTCSNPQHSC 326
            .:||..|.||||||||||:|||.|||||.||:|.||.:.||||||||||||..|:||||||||||
Mouse   263 ARPGQPNCSCATLSEYSRRCSMTGQPVRNWRTPALCPMSQCPANQVYQECGEVCIKTCSNPQHSC 327

Human   327 SSSCTFGCFCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLGRWVCTER 391
            ||.||||||||.||:|:|:|.|.:||||.||||:|:|.:|.|||:|..|||||:||:|||.||::
Mouse   328 SSPCTFGCFCPHGTLLDDISGNQSCVPVNQCPCMLNGMVYGPGEITKTACQTCQCTMGRWTCTKQ 392

Human   392 PCPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHSETSLVAVVY 456
            ||||||||||||||||||||||||||||||.||||||||.:|.|||||||||.|||||||||::|
Mouse   393 PCPGHCSLEGGSFVTTFDARPYRFHGTCTYTLLQSPQLPNEGTLMAVYDKSGYSHSETSLVAIMY 457

Human   457 LSRQDKIVISQDEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMATSFGLELVVQLRPIFQAYVTV 521
            ||::||||||:|||:||||:.|.|||||.|||:||||||||||||:||||||.|::|:||.|:||
Mouse   458 LSKKDKIVISEDEVITNNGDTKLLPYKTHNITIFRQTSTHLQMATTFGLELVFQMQPVFQVYITV 522

Human   522 GPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRAGNCPAALERETDPCSMSQLNKV 586
            ||||:||||||||||||||||||||||||.|||||||||||||||||||||||.|||||||||||
Mouse   523 GPQFKGQTRGLCGNFNGDTTDDFTTSMGIDEGTASLFVDSWRAGNCPAALEREMDPCSMSQLNKV 587

Human   587 CAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACNYEETFPHICAALGDYVHACSLRGVLLW 651
            ||||||||||:.|:|||:||:.|||.|||||||||||||||||||||:|||.|.||||.||:|||
Mouse   588 CAETHCSMLLKKGSVFEKCHSVVNPQPFYKRCVYQACNYEETFPHICSALGAYAHACSARGILLW 652

Human   652 GWRSSVDNCTIPCTGNTTFSYNSQACERTCLSLSDRATECHHSAVPVDGCNCPDGTYLNQKGECV 716
            |||:||||||:|||||.||||:||||:|||||||||.||||.|.|||||||||:|||||.|.|||
Mouse   653 GWRNSVDNCTVPCTGNRTFSYDSQACDRTCLSLSDRETECHVSPVPVDGCNCPEGTYLNHKAECV 717

Human   717 RKAQCPCILEGYKFILAEQSTVINGITCHCINGRLSCPQRPQMFLASCQAPKTFKSCSQSSENKF 781
            .||||||:|:.|||:.|:|||:|||:.|||||||||||::.:||.|||..||||:|||||||:||
Mouse   718 HKAQCPCLLDDYKFVQADQSTMINGVICHCINGRLSCPRQAEMFFASCPEPKTFQSCSQSSEDKF 782

Human   782 GAACAPTCQMLATGVACVPTKCEPGCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGAELHTDC 846
            ||||||||||||||:.|||||||.||||.:|||||:||||||.|||||:::|||||||.||||||
Mouse   783 GAACAPTCQMLATGIDCVPTKCESGCVCPKGLYENSDGQCVPAEECPCDYAGVSYPGGFELHTDC 847

Human   847 RTCSCSRGRWACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCGVNDSQPTFKIL 911
            :||:||:|||.||..|.|||||.||||||:||||||||||||:|||:||||.||.|.||||||:|
Mouse   848 KTCTCSQGRWTCQLSTQCPSTCVLYGEGHIITFDGQRFVFDGDCEYMLATDDCGANSSQPTFKVL 912

Human   912 TENVICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPGALSLVVDISIPGRYNL 976
            |||||||.|||||||||||.||||.:.:||.||||:||||.|.|.|.|..|:||:||.||||.||
Mouse   913 TENVICGKSGVTCSRAIKISLGGLFITMADSNYTVSGEEPLVHLKVKPSPLNLVLDIDIPGRLNL 977

Human   977 TLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYVASSELELVNSWKESPLCGDVS 1041
            ||:||:||::.|:|.||:||.|||||||.||||||||||||:||||:|||.||||||||||||.|
Mouse   978 TLVWNKHMSVSIKIRRATQDALCGLCGNANGNMKDDFETRSKYVASNELEFVNSWKESPLCGDAS 1042

Human  1042 FVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLPYYEACVRDACGCDSGGDCECLCDAVA 1106
            :..||||||.||||||||||::|||||||.||||||||||||||||||||||:||||||||||||
Mouse  1043 YAVDPCSLNTFRRSWAERKCNIINSQTFAACHSKVYHLPYYEACVRDACGCDTGGDCECLCDAVA 1107

Human  1107 AYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWHYQPCLCPSQPQSVPG 1171
            |||:||||||||||||||.||||||.||||||..|..||||.||:||||||||||||....|.|.
Mouse  1108 AYAKACLDKGVCVDWRTPDFCPIYCDFYNTHTLVGENEYQYAQESNCTWHYQPCLCPGSLGSFPD 1172

Human  1172 SNIEGCYNCSQDEYFDHEEGVCVPCMPPTTPQPPTTPQLPTTGSRPTQVWPMTGTSTTIGLLSST 1236
            :|.||||||||:|||||.||.||||.||||..|||     ||||:||       |.|||   |:.
Mouse  1173 TNTEGCYNCSQNEYFDHSEGTCVPCAPPTTTLPPT-----TTGSQPT-------TETTI---STE 1222

Human  1237 GPSPSSNHTPASPTQTPLLPAT--------------LTSSKPTASSGEPPRPTTAVTPQATSGLP 1287
            ..|.:|.:||.:|:..|.||..              .|..:.|.||||.|:.|.|.|| .||..|
Mouse  1223 FHSSTSANTPVAPSYLPGLPTPPPSAPSSTEELTVWTTPKESTVSSGEYPQTTMAATP-PTSPWP 1286

Human  1288 PTATLRSTATKPTVTQATTRATASTASPATTSTAQSTTRTTMTLPT--PA-------TSGTSPTL 1343
            ||:..:||.|:..|||||::.|||:.|.:|.:||:.|..||:||.|  |.       ||.:..|.
Mouse  1287 PTSIPKSTPTELPVTQATSKPTASSLSSSTKTTAELTESTTVTLLTLMPGMSTSQGKTSASYTTQ 1351

Human  1344 PKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTHS 1408
            .:||:..|...:...|.|...||...|...||.....|                      |.|::
Mouse  1352 HQSTSFHLTTISKWPTNGVSDTPGVHTSSGTPSSSHAT----------------------HITYT 1394

Human  1409 PPT--AGSPVPSTGPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMA 1471
            |||  ..|...||||...||...|..:||.|.|:|:|.|..|..|:|....::..:.|||.:||.
Mouse  1395 PPTQVVSSITHSTGPPLGTSVQTTINFPTLSAPQTSLVTPHPGLSSSSTALTSEILKTPTSSQMV 1459

Human  1472 TSASNHSAPTGTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSH--TSSTHH 1534
            :|||..:. ..:|.|.|||:||...||||.||..||..:||.|||||:||.||.||.  |.:.|.
Mouse  1460 SSASPQTI-FSSIHPKTTLEATTPQHTAPLITSITSSITQAQSSFSTDKTYTSQHSQPSTMTAHQ 1523

Human  1535 PEVTPTSTTTITPNPTSTRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFS---------STGP 1590
            ....||.||  :...|...|.||..||.|.|:|.|..|.|||       |||         :||.
Mouse  1524 SRSLPTVTT--STKSTMGLTGTPPVHTTSGTTSSPQTPRTTH-------PFSTVAVSNTKHTTGV 1579

Human  1591 MTATSFKTTTTYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPP 1655
            ...||.:||...||||.|||:|.||:|..|||.|||::..:||||.....:|||. |..||.| .
Mouse  1580 SLETSVQTTIASPTPSAPQTSLATHLPFSSTSSVTPTSEVIITPTPQHTLSSAST-STTTGNI-L 1642

Human  1656 PTTLKATGSTHTAPTMTLTTSGTSQALSSLNTAKTSTSLHS-HTSST-----HHAEATSTSTTNI 1714
            |||:..|||.||:..:..|||..:|..:|.:|.:|||...: |.|.|     |.:..|:.|..:|
Mouse  1643 PTTIGQTGSPHTSVPVIYTTSAITQTKTSFSTDRTSTPTSAPHLSETSAVTAHQSTPTAVSANSI 1707

Human  1715 TPNPTSTGTP------------------------------------------------------- 1724
            .|..:|||||
Mouse  1708 KPTMSSTGTPVVHTTSGTTSSPQTPRTTHPSTTVAVSGTVHTTGLPSGTSVHTTTNFPTHSGPQS 1772

Human  1725 ---------------------------------------------------------PMTVTTSG 1732
                                                                     |:|.||:.
Mouse  1773 SLSTHLPLFSTLSVTPTTEGLNTPTSPHSLSVASTSMPLMTVLPTTLEGTRPPHTSVPVTYTTTA 1837

Human  1733 TSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSI---TPNHTSTG--TRTPVAHTTSATSSR 1792
            .:|::|||||.:|||. |...|||    ||.|.:|.|   |.:..:||  |.||..||||.|:|.
Mouse  1838 ATQTKSSFSTDRTSTP-HLSQSST----VTPTQSTPIPATTNSLMTTGGLTGTPPVHTTSGTTSS 1897

Human  1793 LPTPFTTHSPPTGTTPISSTGPVTA----TSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTH 1853
            ..||.|||  |..|..:|:|...|.    ||.|||...||||.|.|:|.||:|..|||.|||::.
Mouse  1898 PQTPRTTH--PFSTVAVSNTKHTTGVSLETSVQTTIASPTPSAPQTSLATHLPFSSTSAVTPTSE 1960

Human  1854 TVIIPTHTQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSL 1918
            .:|.||.....:|||. |..||.| .||||..|||.||:.|:..|||..:|:.:||||.:||||
Mouse  1961 VIITPTPQHTFSSAST-STTTGNI-LPTTIGQTGSPHTSVPVIYTTSAITQTKTSFSTDRTSTS- 2022

Human  1919 PYHTSSTHHPEV--------TPT--STTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSP-- 1971
               ||:.|..|.        |||  |..:|.|..:|||  |||.||||.::|...||.|||..
Mouse  2023 ---TSAPHLSETSAVTAHQSTPTAVSANSIKPTMSSTG--TPVVHTTSGTTSSPQTPRTTHPSTT 2082

Human  1972 ------------PTGSS------------------------------------------------ 1976
                        |:|:|
Mouse  2083 VAVSGTVHTTGLPSGTSVHTTTNFPTHSGPQSSLSTHLPLFSTLSVTPTTEGLNTQSTPIPAITN 2147

Human  1977 -------------------------------PFS---------STGPMTATSFQTTTTYPTPSHP 2001
                                           |||         :||....||.|||...||||.|
Mouse  2148 SLMTTGGLTGTPPVHTTSGTTSSPQTPRTTHPFSTVAVSNTKHTTGVSLETSVQTTIASPTPSAP 2212

Human  2002 QTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATSASIHSTPTGTVPPPTTLKATGSTHTAPPMTV 2066
            ||:|.||:|..|||.||| |..||||...|...|::..||.||.: .|||:..|||.||:.|:..
Mouse  2213 QTSLATHLPFSSTSSVTP-TSEVIITPTPQHTLSSASTSTTTGNI-LPTTIGQTGSPHTSVPVIY 2275

Human  2067 TTSGTSQTHSSFSTATASSSFISSSSWLPQNSS-----SRPPSSPITTQLPHLSSATTPV--STT 2124
            |||..:||.:||||...|:.  :|:..|.:.|:     |.|.:....:..|.:||..|||  :|:
Mouse  2276 TTSAITQTKTSFSTDRTSTP--TSAPHLSETSAVTAHQSTPTAVSANSIKPTMSSTGTPVVHTTS 2338

Human  2125 NQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVGTSSSFVSAPVHSTTLSSGSHSSLSTH-PT 2188
            ...||..:|..:.|||..:...:.|::...|..||.|:::|   |.|     ||..|||||| |.
Mouse  2339 GTTSSPQTPRTTHPSTTVAVSGTVHTTGLPSGTSVHTTTNF---PTH-----SGPQSSLSTHLPL 2395

Human  2189 TASVSASPLFPSSPAASTTIRATLPHTISSPFTLSALLPISTVTVSPTPSSHLASSTIAFPSTPR 2253
            .:::|.:   |::...:|   .|.||::|...|...|:.:...|:..|...|     .:.|.|..
Mouse  2396 FSTLSVT---PTTEGLNT---PTSPHSLSVASTSMPLMTVLPTTLEGTRPPH-----TSVPVTYT 2449

Human  2254 TTASTHTAPAFSSQSTT----SRSTSLT----TRVP-TSGFVSLTSGVTGIP---------TSPV 2300
            |||:|.|..:||:..|:    |:|:::|    |.:| |:..:..|.|:||.|         :||.
Mouse  2450 TTAATQTKSSFSTDRTSTPHLSQSSTVTPTQSTPIPATTNSLMTTGGLTGTPPVHTNSGTTSSPQ 2514

Human  2301 TNLTTRHPGPTLSPT-------TRFLTSSLTAHGSTPASAPVSSLGTPTPTSPGVCSVREQQEEI 2358
            |..|| ||..|::.:       ....||..|...|...|||.:||.|..|.| ...||..
Mouse  2515 TPRTT-HPFSTVAVSNTKHTTGVSLETSVQTTIASPTPSAPQTSLATHLPFS-STSSVTP----- 2572

Human  2359 TFKGCMANVTVTRCEGACISAASFNIITQQV 2389
                 .:.|.:|......:|:||.:..|..:
Mouse  2573 -----TSKVIITPTPQHTLSSASTSTTTGNI 2598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUC6	NP_005952.2	VWD	40..192	CDD:214566	114/152 (75%)
		C8	228..297	CDD:285899	46/68 (68%)
		TIL	302..357	CDD:280072	42/54 (78%)
		VWC_out	359..>403	CDD:214565	30/43 (70%)
		VWD	386..549	CDD:214566	135/162 (83%)
		C8	588..660	CDD:285899	58/71 (82%)
		TIL	664..721	CDD:280072	46/56 (82%)
		TIL	782..827	CDD:280072	37/44 (84%)
		VWC	829..886	CDD:302663	43/56 (77%)
		VWD	868..1017	CDD:278521	112/148 (76%)
		C8	1057..1127	CDD:285899	63/69 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1455		97/277 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1471..1626		75/165 (45%)
		1, truncated	1561..1738		81/303 (27%)
		Approximate repeats	1607..1953		167/482 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1642..1834		91/318 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1983		60/226 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2033..2077		19/43 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2090..2196		36/113 (32%)
		PHA03255	2188..>2343	CDD:165513	51/179 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2233..2278		15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2348		10/24 (42%)
		CT	2351..2434	CDD:214482	7/39 (18%)
Muc6	NP_001355882.2	VWD	45..194	CDD:395046	111/148 (75%)
		C8	232..298	CDD:400886	45/65 (69%)
		TIL	303..358	CDD:396409	42/54 (78%)
		VWC_out	360..>404	CDD:214565	30/43 (70%)
		VWD	387..550	CDD:214566	135/162 (83%)
		C8	589..661	CDD:214843	58/71 (82%)
		TIL	665..722	CDD:410995	46/56 (82%)
		TIL	765..828	CDD:410995	51/62 (82%)
		VWC_out	830..887	CDD:214565	43/56 (77%)
		VWD	869..1020	CDD:395046	114/150 (76%)
		C8	1057..1129	CDD:214843	65/71 (92%)
		ROM1	1406..>1624	CDD:227709	101/227 (44%)
		Herpes_BLLF1	<1553..1968	CDD:282904	141/430 (33%)
		Herpes_BLLF1	<1858..2241	CDD:282904	144/397 (36%)
		PHA03247	<2099..2563	CDD:223021	144/487 (30%)
		Herpes_BLLF1	<2510..2925	CDD:282904	28/101 (28%)
		Herpes_BLLF1	<2791..3187	CDD:282904
		PHA03247	<3329..3784	CDD:223021
		COG3889	<3886..4052	CDD:226406
		Herpes_BLLF1	<4013..4471	CDD:282904
		PHA03247	<4320..4742	CDD:223021
		CT	4847..4926	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970298
Domainoid	1	1.000	673	1.000	Domainoid score	I4089
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18768
Inparanoid	1	1.050	2534	1.000	Inparanoid score	I895
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38406
OrthoDB	1	1.010	-	-		D12226at2759
OrthoFinder	1	1.000	-	-		FOG0004663
OrthoInspector	1	1.000	-	-		otm51537
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11339
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11601
SonicParanoid	1	1.000	-	-		X10405
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.540