DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpE1 and AIP5

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_116671.1	Gene:	AIP5 / 850570	SGDID:	S000001912	Length:	1233	Species:	Saccharomyces cerevisiae

Alignment Length:	1290	Identity:	274/1290 - (21%)
Similarity:	468/1290 - (36%)	Gaps:	368/1290 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 AADQEDQKQEQAVEKVEQPASSTTTTTTTTTTPRPT-----TRTTSRTTTTTTAA------PP-- 235
            |...:.::::..:|        ..|.|....|..||     .....:.|:|...|      ||
Yeast   114 AISHDLERKDDVIE--------IATDTINDATESPTQIPIDVNVVIKETSTNNVAEGTENVPPIK 170

  Fly   236 ----------------------TTTRR---TTTTTTTTTPAPILLEDELPASVEEQSLEEDDGET 275
                                  ||.||   ::....||..:.....|.:...:||. |:||..:.
Yeast   171 ESTGIEVGNSPITRRKKNKKKKTTNRRGRNSSNPADTTDLSKQSTLDSILVGIEEY-LQEDGSKN 234

  Fly   276 TKLRPEVVEVD--NGEKLEAVDLAHEETELT-----QQQNQLDEQQHQEEEQKHQEEEQHRIEQQ 333
            ..::..:|:.:  |.||:: :...:|.::.|     ..::.:||...:.|...::|:.:|.:.::
Yeast   235 EDIKVNIVQDEPVNVEKMD-IRTRNESSDKTFDIDVPNKDNVDETSSKSENNINEEKAEHTLPRE 298

  Fly   334 QNQ----------EEEQQQQQHQQQVIDQASDAELPQSSQDATT----------------GVQQL 372
            :|:          ..:.|.:.|..:..|:...|.......::.|                |.:|
Yeast   299 ENEILNVNEGNAASFKHQLEPHGLEAGDENGQASTKDVESESLTKNGFNFKENESKHLKAGEKQ- 362

  Fly   373 LTPADVPTEDAINA------EQETEAGPTEDYPYKIDEEYTEEHNDKPE---APELTVDQPEHE- 427
            .|.:|   .|.|:.      ::|||.|         .|::..|..||.:   ..||:|:   ||
Yeast   363 QTESD---RDGISPSVLAKNQKETEIG---------KEDHVFEQKDKEDEKCRKELSVN---HEN 412

  Fly   428 ------ESPVATEIVPIEADEEAAEASGGQEIASSPIDDTMKFDYETSVDDVEPAKPEDEKETEA 486
                  .:..:..|:|.|.:.|..:            |:||           .|.|...:.|...
Yeast   413 NMSHNFNAAGSDSIIPPETERETYD------------DETM-----------GPTKRISDNEKNL 454

  Fly   487 VHQATNEGVVPIDTESETDAETSTEPQIQTQLLQEDGEPETSQTVADEELIPVNEGETESVTKAA 551
            .| .||:  :.::.|.|.:.|            :|:.|..|...|..|.:    .||.|:|..
Yeast   455 QH-GTND--ISVEVEKEEEEE------------EEEEENSTFSKVKKENV----TGEQEAVRN-- 498

  Fly   552 DETEEIPEEETP--EDLASGDH------------ELDVAAASH---------DDEVETPKQE-EP 592
            :|.....||.|.  |::..||.            |::.:|.|.         :||.|.|.|| :|
Yeast   499 NEVSGTEEESTSKGEEIMGGDEKQSEAGEKSSIIEIEGSANSAKISKDNLVLEDEAEAPTQENKP 563

  Fly   593 TEALKIEQPAQVESESQNVDEVGKPEEPQAEMEIEKEKEETAATEAAEVELPATEAKPDMESEID 657
            ||.               |.|:..|:.|:.::||.:..|:....|..||      ||.|.|.|
Yeast   564 TEV---------------VGEIDIPDAPRDDVEIVEAVEKNIIPEDLEV------AKEDQEGE-- 605

  Fly   658 QVEQSADIKPTSGEDDLNEANQLNQDQVTEPA-ALEQEEIEEKEPEQVVDMHEDADEATTEKPVQ 721
                                    |.::.||. |::.::|..:..|.:.:..:...|.|.|...:
Yeast   606 ------------------------QVKLDEPVKAMKDDKIAMRGAESISEDMKKKQEGTAELSNE 646

  Fly   722 DHDQEEVEAITEAEHGQLTYPTNDDELAPVEIEPELTTEEPEIAEN-TTELPEQQQ-QQQDEEEI 784
            ...:|..|...|:..|             ||:|...|.|.|::.:. |:..||..| .::|.|.:
Yeast   647 KAKKEVDETARESAEG-------------VEVEKSKTPESPKVVKRCTSGRPEDLQINERDPEVL 698

  Fly   785 EEAALAHEEQVQQVEPEENANAIKTPEVSEAIAEPQADLETPSATEKEIEPQTADHVEEE--PVA 847
            :|.....:|.|:             ||::..|  ..::.|.|.:...:|..:.|:..:::  .|.
Yeast   699 KEDVRVPDEDVK-------------PEIATTI--ENSEEEDPKSQRVQISTEQAETTQKDMGDVG 748

  Fly   848 ITERIQEAEPEPEIEPT--NDEVSQVD-------ADQAEPELPIKSDADIAEEAAEEPAQTEVAP 903
            .|...:|.|.....|.|  .|:::..|       |.:|..|....||...||:.. ||:...|..
Yeast   749 STTSFKEEEKPKRFEITQEGDKITGKDTNHEHGEATEAASENSKASDVGTAEKYI-EPSSESVKK 812

  Fly   904 EVETETEASESAQTSPEISVEQDEVAIDKNENDNIIQGAEPNEEDELIPEPQPMPEEEELPVQQE 968
            :.|.:.|...|         |:.|....|.|.:|:    :..:|.|:..|..  .|.|::.|..|
Yeast   813 DTEEDAEVENS---------EKTEFIKVKAELENL----DAPKEAEVTAELN--KENEDVEVDTE 862

  Fly   969 ASAVPEDHKLTKPEMDYTSVE-HLQELSRPEETTAAIEAEESDSRESTLAPEAPDAPIAIVSEE- 1031
            ..|..|:.:.|    ::..|: .|..|..|:|  |.:.||        |..|..|..:|..|:|
Yeast   863 EDAEVENSEKT----EFIKVKAELGNLDAPKE--AEVTAE--------LNKENEDVEVAATSKED 913

  Fly  1032 -----RDPEHDPQNFHESESIADILSDLMLEADSTVPPVPFGQQPAQTVPMVEANSENEEEQAHE 1091
                 .:|...|                 :| |.|.......::.|:.|...:.|.||  .:..|
Yeast   914 IETKCSEPAETP-----------------IE-DGTCTEAEVSKKDAEAVTKEDENMEN--SKIAE 958

  Fly  1092 AISDLQAE--------ADETQEHAEQVQPVNEPGTAIPELFAEAAKDE--EDVPALPESDESKTE 1146
            |:.|:..:        :||.|...|           :|||..:..||.  ||.....|..|.:|.
Yeast   959 ALKDVTGDQEIDDINISDEFQRTVE-----------LPELEKQDIKDNKGEDKELEVEETEKETS 1012

  Fly  1147 QPSALEVEQHIASEAEQTPVEDEH--QYDEEEHQQDQEEHQQDEDEPLKEVETESLPEEATTEKF 1209
            .|. |.||::|..|..:...|:|.  |.|..|.:...:|...:::...::..|...|::|:.:..
Yeast  1013 LPD-LVVEENITEEKNEIKQEEEEVSQLDFNETESISKEAPNNDENGFEDQSTRENPKKASADDI 1076

  Fly  1210 QEPEPEEVNTPLPEELPFDLTDHSDVNRFNELQSESLILESTTNIDGLQELDNNHIEEEEPAAHA 1274
            .:...:|.|..| |:|  .:.|.|::|..    .:||..:.:|.....|...||    ::|....
Yeast  1077 FKDILDETNEFL-EQL--KIVDDSELNAL----LQSLDAKDSTTQTTEQSKKNN----DKPQDVI 1130

  Fly  1275 IPHEEATPNPADIVEITTQT------MLGLASRVTLMEPAAPVVTTLMPLMTADE 1323
            ...|....|..:.|.|.|..      |:...:|::.:..|..:..|...|.|.||
Yeast  1131 TTSEIRKLNEKEPVYIYTSLAGGGFHMIPRTNRLSTILTANRIPFTYRDLGTDDE 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060
		LDLa	1448..1483	CDD:238060
		LDLa	1493..1524	CDD:238060
		LDLa	1561..1590	CDD:238060
AIP5	NP_116671.1	2A1904	<271..>528	CDD:273344	62/316 (20%)
AIP5	NP_116671.1	PTZ00121	<482..1082	CDD:173412	167/742 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000