DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpE1 and SORL1

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_003096.2	Gene:	SORL1 / 6653	HGNCID:	11185	Length:	2214	Species:	Homo sapiens

Alignment Length:	394	Identity:	110/394 - (27%)
Similarity:	151/394 - (38%)	Gaps:	102/394 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1288 VEITTQTMLGL-------ASRVTLMEPAAPVVTTLMPLMTADEP----TPEPVSPAAIPSASLAA 1341
            :||....:.||       ..:.|......|...:|:.|..|:..    .||.||.:.:||..|..
Human   994 MEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMC 1058

  Fly  1342 IKP-GTELRKRVDLGLEAVSLGLA--------------CSSDRQC-QLAD----PHTVCN----- 1381
            ..| |.:|:....:..|...|...              |..|..| .::|    |.|:|:
Human  1059 DCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQF 1123

  Fly  1382 ---RRGVC-----------DCAAGEEGSQCSAERTGCSPGTFQCRSSGVCISWFFVCDGRADCND 1432
               ..|.|           ||....:.|.|  |...|....:.| |||:||...:||||..||.|
Human  1124 RCQESGTCIPLSYKCDLEDDCGDNSDESHC--EMHQCRSDEYNC-SSGMCIRSSWVCDGDNDCRD 1185

  Fly  1433 ASDE-ECTHNARLNQTCPTESFRCQRSGRCISRAALCDGRRQCPHGEDE--LGCDGSVKGGNACP 1494
            .||| .||   .:..||...:|:| |:|.||.:...|||...|..|.||  :.|:....|
Human  1186 WSDEANCT---AIYHTCEASNFQC-RNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG----- 1241

  Fly  1495 EHTFRCGSGECLPEYEYCNAIVSCKDGSDEP----------PHLCGSRALPNLFMRLIEAGGLL- 1548
               |||.:|.|:|..::|:.:..|.|||||.          ..:|.:|. ..||..:: ..|::
Human  1242 ---FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQ-QCLFHSMV-CDGIIQ 1301

  Fly  1549 ---GGGRREADAYCPH-------------RCSNGLCRSTAIVCSGRDGCGDGTDEQTCSVCRCPA 1597
               |.....|.|.|..             :|.||:|.|....|.|.|.|||.:||     ..|..
Human  1302 CRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE-----ANCEN 1361

  Fly  1598 PTAA 1601
            ||.|
Human  1362 PTEA 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	17/33 (52%)
		LDLa	1448..1483	CDD:238060	14/36 (39%)
		LDLa	1493..1524	CDD:238060	11/30 (37%)
		LDLa	1561..1590	CDD:238060	13/41 (32%)
SORL1	NP_003096.2	Cell attachment site. /evidence=ECO:0000255	63..65
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		LY	780..821	CDD:214531
		LDL-receptor class B 1	800..843
		LY	824..866	CDD:214531
		LDL-receptor class B 2	844..887
		LY	868..910	CDD:214531
		LDL-receptor class B 3	888..932
		Ldl_recept_b	890..929	CDD:278487
		LY	913..953	CDD:214531
		LDL-receptor class B 4	933..970
		LDL-receptor class B 5	971..1013		4/18 (22%)
		LDLa	1078..1112	CDD:238060	5/33 (15%)
		LDLa	1120..1153	CDD:238060	5/32 (16%)
		Ldl_recept_a	1157..1192	CDD:278486	17/35 (49%)
		LDLa	1198..1230	CDD:197566	13/32 (41%)
		LDLa	1240..1271	CDD:238060	14/38 (37%)
		LDLa	1281..1308	CDD:197566	6/28 (21%)
		LDLa	1325..1359	CDD:238060	13/38 (34%)
		LDLa	1373..1403	CDD:238060
		LDLa	1419..1453	CDD:238060
		LDLa	1471..1506	CDD:238060
		LDLa	1513..1546	CDD:197566
		FN3	1557..>1628	CDD:238020
		FN3	1651..1742	CDD:238020
		FN3	1749..1829	CDD:214495
		FN3	1934..2021	CDD:238020
		FN3	2025..2112	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305\|PubMed:16531402	2161..2164
		Endocytosis signal. /evidence=ECO:0000255	2172..2177
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269\|PubMed:17646382	2190..2214
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269\|PubMed:11821067	2201..2214
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269\|PubMed:20015111	2208..2212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900