DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpE1 and ldlrad3

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_001124079.1	Gene:	ldlrad3 / 570705	ZFINID:	ZDB-GENE-030131-1533	Length:	314	Species:	Danio rerio

Alignment Length:	269	Identity:	73/269 - (27%)
Similarity:	97/269 - (36%)	Gaps:	59/269 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1384 GVCDCAAGEEGS---QCSAERTGCSPGTFQCRSSGVCISWFFVCDGRADCNDASDEE-CTHNARL 1444
            |..||.....|:   .|||      ||:|.| :.|.|:.....|||..||.|.|||. |   .:|
Zfish    11 GSVDCQVSPGGNSSWHCSA------PGSFMC-ADGECVPAAGQCDGYPDCADRSDERGC---LKL 65

  Fly  1445 NQTCPTESFRCQRSGRCISRAALCDGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEY 1509
            ...|.:..|.|.....||.....|:|.|.||.|.||..|.....   .|....|.|.:|.|:...
Zfish    66 KSKCASTFFSCANGVHCIIGRFQCNGFRDCPDGSDEDNCTAHPL---LCSSLRFHCANGRCVDRS 127

  Fly  1510 EYCNAIVSCKDGSDE---------PPHLCGS-----RALPN----------LFMRLIEAGGLLGG 1550
            ..||...:|:|.|||         |.|:.|:     |..|:          :|:.::....|:..
Zfish   128 FLCNGQDNCQDNSDEENCLTTAESPEHMLGTLDYRLRYYPSITYAVIGSAIIFVLVVALLALVLH 192

  Fly  1551 GRREADAYCPHRCSNGLCRS------TAIVCSGRDGCGDGTDEQTCSVCRCPAPTAASLPAF--L 1607
            .:|:.....|.|...|.|..      ..||..|          ......|||...|...|::  .
Zfish   193 HQRKRSVLLPQRVYRGSCHQPLLLSRLLIVERG----------HLLHPSRCPGAPADLPPSYSQA 247

  Fly  1608 ARQRPMPLW 1616
            .|....|:|
Zfish   248 VRDSGRPVW 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	14/32 (44%)
		LDLa	1448..1483	CDD:238060	13/34 (38%)
		LDLa	1493..1524	CDD:238060	10/30 (33%)
		LDLa	1561..1590	CDD:238060	6/34 (18%)
ldlrad3	NP_001124079.1	LDLa	30..62	CDD:238060	15/32 (47%)
		LDLa	69..104	CDD:238060	13/34 (38%)
		LDLa	111..145	CDD:238060	12/33 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900