DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpE1 and akap12b

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_001268717.1	Gene:	akap12b / 567365	ZFINID:	ZDB-GENE-030131-9753	Length:	1596	Species:	Danio rerio

Alignment Length:	1542	Identity:	332/1542 - (21%)
Similarity:	551/1542 - (35%)	Gaps:	471/1542 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 APAADQEDQKQEQAVEKVEQPASSTTTTTTTTT-------TPRPTTRTTSRTTTTTTAAPPTTTR 239
            :|...:.:.|.|:..||.|:||..|.....:.|       |.:|...|  .|.:.....|.....
Zfish   192 SPETTENEAKAEEVTEKAEEPAEQTVVDAPSETEKVSDIETEKPAEET--GTISEKEPEPEVPAE 254

  Fly   240 RTTTTTTTTTPAPILL-------------------EDELPASVEEQSLEEDDGETTKLR---PEV 282
            ..|:..:..|.:|...                   :||  ..|:|:.:|||..||.:..   ||.
Zfish   255 SPTSPPSQETQSPFKRFFTQGIFSNLRKKASFKKPKDE--EHVKEKPVEEDIKETEETAEGVPEA 317

  Fly   283 VE---VD------NGEKL----EAVDLAHEETELTQQQNQLDEQQHQEEEQ---KHQEEEQHRIE 331
            .|   ||      .||::    |.|:...|.|..|..:...:....::|||   |.:.|....:|
Zfish   318 TEEAKVDAENEPAEGEQIEKPSETVETKAETTTETTAETTNEVTPTEKEEQQDLKVEAEATSEVE 382

  Fly   332 QQQNQEEEQQQQQHQQQVIDQASDAELPQSSQDATTGVQQLLTPADVPTEDAINAEQE------- 389
            ...:.|..|.......|..|.|..::.|..|::|             |||..|.:.||
Zfish   383 TVTHTEPAQAPAVETTQPTDDAKTSDKPDISEEA-------------PTEPEILSSQEKSKAHGS 434

  Fly   390 ------TEAG----PTEDYPYKID--------EEYTEE-----HNDKPEAPELTVDQPEHEESPV 431
                  |.||    .::.:..|.|        .|.|.|     .:.:|:.|:.....||.....|
Zfish   435 PLKKLFTGAGLKKLSSKKHKNKKDAESKQTESSEQTAETVQSTESTEPQKPDSGASSPEESGEHV 499

  Fly   432 ATEIV------PIEADEEAAEASG----------------------------------GQEIASS 456
            ..|:.      .:|.|.:|..:.|                                  |.:..||
Zfish   500 VGEVAQAEVAQAVEPDGDAVTSDGEKKKEGILPWSSFKKLVTPKKRVKRPSESEDEAPGDKPKSS 564

  Fly   457 PIDDTMKFDYETSVDDVEPAKPEDEKETEAVHQATNEGVVPIDTESETDAETSTEPQIQ-TQLLQ 520
            .:..|     |:::.|.:..:|:..:|..:..:...|      .:.|:.||:.|||:.: ::.:.
Zfish   565 TLSST-----ESAISDEKADEPKPSEEVPSKEELKEE------AKEESQAESKTEPKAEKSESVA 618

  Fly   521 EDGEPETSQTVADEELIPVNEGE--TESVTKAADETEEIPEEETPED-----------LASGDHE 572
            |:.:.:...:|:.|.||.|...:  ....:.:.||..:|.||..|.:           ::||:.:
Zfish   619 EEPKRKMDTSVSWEALICVGSSKKRARKTSDSDDEEAKIEEEVQPSEEEPIKTAESPLVSSGEAD 683

  Fly   573 LDVAAASHDDEVETPKQEEPTEALKI-EQPAQVESESQNVDEVGKPEEPQAEMEIEKEKEETAAT 636
            .:..|:|.:.|.|.....|..:.|.. .:.|:.|.:|   ||...||:..::.|..||:...:..
Zfish   684 HENLASSPEPEGELVSTWESFKRLVTHRKKAKAEDKS---DEASGPEQTTSDSETPKEESSFSLR 745

  Fly   637 EAAEVELPATEAKPD-----MESEIDQVEQSAD---IKPTSGEDD------LNEANQLNQDQVT- 686
            :.    :|..:.|.|     :.|::...|..:|   :.|.|..|.      ..:|.::.|:..|
Zfish   746 KL----IPRRKKKSDGKQEQVSSDVGSAEDDSDTPAVVPLSEYDSEPSAEAAVKAEEVKQESATV 806

  Fly   687 --EPAALEQ----------EEIE-EKEPEQVVDMHEDADEATTEKPVQDHDQEEV-----EAITE 733
              ..|:.|.          |.:| |.|..|:.|:.|:.|.|.|.|...:...|::     ||:|.
Zfish   807 TQAKASAEDRSPSWISTTVENVEDETEGNQLSDIPEEGDTAATPKSTDNTIAEDIVELTSEAVTA 871

  Fly   734 AEHGQLTYPTNDDELAPVEIEPEL------TTEEPEIAENTTELPEQQQQQQDEEEIEEAALAHE 792
            .|.              || |.|:      .|..|:.:..||.:|....:::.:..|:||
Zfish   872 LEQ--------------VE-ETEMVSAVSRVTASPDTSGETTPVPGDGVERKTDVVIQEA----- 916

  Fly   793 EQVQQVEPEENANAIKTPEVSEAIAEPQAD-LETPSATEKE------------------IEPQTA 838
              |:.:....||.|:...|..|.:.....| |...|||:::                  ::....
Zfish   917 --VETISVTTNAMAVTMTEEQETVVAITTDALLVESATKEQKTVLVAHEKNEAVAVCTGLDTSEI 979

  Fly   839 DHVEEE----------------PVAITERIQEAEPEPE-IEPTNDEVSQVDADQAEPELPIKSDA 886
            ..||||                |:.....::|...||| :..|.|||.:......:.||   .|.
Zfish   980 RAVEEESLNQKPSVESATVVSQPLVTEVAVEEKTQEPERVTVTEDEVHEAQTSGVQAEL---KDQ 1041

  Fly   887 DIAEEAAEEPAQTEVAPEVETETEASESAQTSPEISVEQDEVAIDKNENDNIIQGAEPNEEDELI 951
            .| |.|.||.||.|       |.:.:..|:|..:|    .|||..|....:.:|     :|.|::
Zfish  1042 PI-ENAIEEKAQFE-------EIKDTPIAETVADI----HEVAAVKVAVISAVQ-----QEPEIL 1089

  Fly   952 PEP---QPMPEEEEL-PVQQ--EASAVPEDHKLTKPEMDYTSVEHLQELSRPEETTAAIEAEESD 1010
            .||   :..||.|.. ||:.  |.:...:..::|  |:.....|.:|||...:||.|.:|.
Zfish  1090 EEPVMAEKSPEIESAGPVEATVEEAICAQTAEVT--EVAVAEGEKVQELDDVKETVATVEV---- 1148

  Fly  1011 SRESTLAPEAPDAPIAIVSEERDPEHDPQNFHESESIADILSDLMLEADSTVPPVPFGQQPAQT- 1074
                                              .|:.::.:.:..|..:|:|.||..|....|
Zfish  1149 ----------------------------------ASVENVSTAVTEEVMATLPEVPASQIAGSTE 1179

  Fly  1075 --VPMVEANSE-------------NEEEQAHEAISDLQAE--------ADETQEHAEQVQPVNE- 1115
              :|:|.|..|             :|..::|.|  |:..|        ...|.:|..|| .|||
Zfish  1180 DPIPVVAATEEFAVIKETICVSSISETTESHSA--DIAKETLMENVPVVLSTGDHKMQV-AVNEV 1241

  Fly  1116 ---PGTAIPELFAEAAKDEEDVPALPESDESKTEQPSALEVEQHIASEAE--------------Q 1163
               ....:.|...|||..:..| ||.|..|:..|:...::..|  .:|||              |
Zfish  1242 EVVSAQGVVEGNIEAASTKLSV-ALEEVTENVKEETEIIQATQ--VTEAEIIEKQSSVIVQEIIQ 1303

  Fly  1164 TPVEDEHQYDEEEHQQDQEEHQQDE------DEPLKEVETESLPEEATTEKF------------- 1209
            ..||:   :.|...:|:..|...:|      :..:.|:..|:..|.::|:|.
Zfish  1304 NVVEN---FAEAHGEQNVSEKTTEESCITSAEVKVNEISVETTEEGSSTDKLAASDNVCKDVEET 1365

  Fly  1210 ---QEPEPEEVN--TPLPEELPFDLTDH-------------SDVNRFNELQSESLIL-------E 1249
               .|..|:.||  ..:.|.:|..:||.             :||::..|:....:.|       :
Zfish  1366 RIVTEKPPKIVNEAIQIAETVPVSITDEIQAQNEEVASVSVADVHQETEVTKSEVELKQAEEKSQ 1430

  Fly  1250 STTNIDGLQELDNNHIE---EEEPAAHAIPHEEATPNPADIVEITTQTMLGLASRVTLMEPAAPV 1311
            ||.|.:|:.|::::..|   |.:....|:|.|:           |.:|.:.:||:..::.....|
Zfish  1431 STKNEEGISEVESDLKEVQAEIQQEIKAVPEEK-----------TAETSVTVASQDQVVAEQCQV 1484

  Fly  1312 VTTLMPLMTADEPTPEPVSPAAIPSASLAAIKPGTELRKRVDLGLEAVSLGLACSSDR-QCQLAD 1375
            ..|.:.:.||.|      ....:.:...|...|.|.::       |..|.|...:.|| |..|.:
Zfish  1485 TLTAVQIETAQE------FNVGVVNVINADDVPETNMK-------EDCSEGQESTEDRPQNDLEE 1536

  Fly  1376 PHTVCN-----RRGVCDC-------------AAGEEGSQC-SAERTG 1403
            |.|..:     .||. ||             ||.|..|.. :||..|
Zfish  1537 PQTKVSTNQEESRGP-DCQKTDAKNVPAKLEAASEMTSNATAAEEVG 1582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	332/1542 (22%)
		LDLa	1448..1483	CDD:238060
		LDLa	1493..1524	CDD:238060
		LDLa	1561..1590	CDD:238060
akap12b	NP_001268717.1	WSK	529..556	CDD:281783	0/26 (0%)
akap12b	NP_001268717.1	WSK	698..724	CDD:281783	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000