Protein Alignment ImpE1 and sorl1

DIOPT Version :9

• Sequence 1: NP_001261577.1
• Gene: ImpE1 / 45879
• FlyBaseID: FBgn0001253
• Length: 1616
• Species: Drosophila melanogaster
• Sequence 2: XP_005157607.1
• Gene: sorl1 / 497306
• ZFINID: ZDB-GENE-050208-22
• Length: 2213
• Species: Danio rerio
• Alignment Length: 339
• Identity: 95/339 - (28%)
• Similarity: 122/339 - (35%)
• Gaps: 111/339 - (32%)

  Fly  1321 ADEP-----TPEP------VSPAAIPSASLAAIKPGTELRKRVDLGLEAVSLGLACSSDRQCQ-- 1372
            ||:|     .|:|      |.|..:|::.|.                         |.:||||
Zfish  1023 ADQPCSLLCLPQPGNQRHCVCPDGVPTSVLP-------------------------SGERQCQCP 1062

  Fly  1373 -----------------LADPHTVCNRRGVC-----------DCAAGEEGSQCSAERTGCSPGT- 1408
                             |.:.|...|  |.|           ||....:..:|..  |.|.|..
Zfish  1063 SGYQLHNNTCVKTEHTCLPNQHRCAN--GKCISSIWKCDSDNDCGDMSDEQECPT--TSCDPSVQ 1123

  Fly  1409 FQCRSSGVCISWFFVCDGRADCNDASDEE-CTHNARLNQTCPTESFRCQRSGRCISRAALCDGRR 1472
            |:|.:||.||...|.||...||.|.|||| |.     :..|....|.|.| |.||..|..|||..
Zfish  1124 FRCVASGSCIPLAFKCDHEDDCGDNSDEEHCE-----SHKCGPGEFTCAR-GACIRDAWRCDGDN 1182

  Fly  1473 QCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDEPPHLCGSRALPNL 1537
            .|....||..|   ..|.:.|...:|:|.:|.|:|:...|:....|:|||||.|..||.:
Zfish  1183 DCRDWSDEANC---TVGHHTCESSSFQCHTGHCIPQRWVCDGDDDCQDGSDEDPTQCGRQ----- 1239

  Fly  1538 FMRLIEAGGLLGGGRREADAYCPHRCSNGLCRSTAIVCSGRDGCGDGTDEQTCSVCRCPAPTAAS 1602
                 :..|.|              ||||.|...:..|:|.:.|..|.|||.|      .|..|.
Zfish  1240 -----KCNGFL--------------CSNGTCLPASAHCNGVEDCPGGADEQNC------GPLCAH 1279

  Fly  1603 LPAFLARQRPMPLW 1616
            ...|:.|.|...|:
Zfish  1280 YMEFVCRNRAQCLF 1293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	16/33 (48%)
		LDLa	1448..1483	CDD:238060	14/34 (41%)
		LDLa	1493..1524	CDD:238060	11/30 (37%)
		LDLa	1561..1590	CDD:238060	12/28 (43%)
sorl1	XP_005157607.1	VPS10	130..754	CDD:214740
		Sortilin_C	589..754	CDD:292523
		LY	781..822	CDD:214531
		LY	825..864	CDD:214531
		LY	868..912	CDD:214531
		LY	916..954	CDD:214531
		LDLa	1079..1113	CDD:238060	7/35 (20%)
		LDLa	1118..1154	CDD:238060	18/35 (51%)
		LDLa	1159..1193	CDD:238060	14/34 (41%)
		LDLa	1242..1273	CDD:238060	14/44 (32%)
		LDLa	1282..1310	CDD:197566	4/12 (33%)
		LDLa	1327..1361	CDD:238060
		LDLa	1376..1405	CDD:238060
		LDLa	1421..1455	CDD:238060
		LDLa	1474..1509	CDD:238060
		LDLa	1522..1551	CDD:238060
		FN3	1559..>1630	CDD:238020
		FN3	1653..1743	CDD:238020
		FN3	1750..1827	CDD:238020
		FN3	1931..2007	CDD:238020
		FN3	2022..2097	CDD:214495

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900