DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpE1 and Lrp3

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_001019878.1	Gene:	Lrp3 / 435965	MGIID:	3584516	Length:	790	Species:	Mus musculus

Alignment Length:	450	Identity:	98/450 - (21%)
Similarity:	118/450 - (26%)	Gaps:	229/450 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly  1304 LMEPAAPVVTTLMPLMTADEPTPEP--VSPAAIPSASLAAIKPGTELRKRVDLGL--EAVSLGLA 1364
            |:.||||             |..|.  :..:|||.|.::|       |..|.:..  :|.|.|.|
Mouse   126 LLGPAAP-------------PRQEAFRLCGSAIPPAFISA-------RDHVWIFFHSDASSSGQA 170

  Fly  1365 ----------------CSSDR-------------QCQLADPHTVCNRRGVCDCAAGEEGSQCSA- 1399
                            |.:|.             ||.:.|           :|..|.:...|||
Mouse   171 QGFRLSYIRGKLGQTSCQTDEFRCDNGKCLPGPWQCNMVD-----------ECGDGSDEGNCSAP 224

  Fly  1400 --ERTG--CSPGTFQCRSSGV----CISWFFVCDGRADCNDASDE-------------------- 1436
              |..|  |..|||.|  ||.    |:.....|||..||.|.|||
Mouse   225 ASEPPGSLCPGGTFPC--SGARSTRCLPVERRCDGTQDCGDGSDEAGCPDLACGRRLGSFYGSFA 287

  Fly  1437 --------------ECT---------------------------------HNARLNQTCPTES-- 1452
                          .||                                 ...||.||....|
Mouse   288 SPDLFGAARGPSDLHCTWLVDTQDPRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNH 352

  Fly  1453 -----------------FRCQRSGR---------------------------------CISRAAL 1467
                             .|.:.:|.                                 |.|....
Mouse   353 RPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSEGDDDSTGEQGCFSEPQR 417

  Fly  1468 CDGRRQCPHGEDELGCDGSVKGGNACPEHTFRC--GSGECLPEYEYCNAIVSCKDGSDEPPHLCG 1530
            |||...|..|.||.||.       |||...:.|  |||.|....:.||...||.||:||..  |.
Mouse   418 CDGWWHCASGRDEQGCP-------ACPPDQYPCEGGSGLCYAPADRCNNQKSCPDGADEKN--CF 473

  Fly  1531 SRALPNLFMRLIEAGGLLGGGRREADAYCPHRCSNGLCRSTAIVCSGRDGCGDGTDEQTC 1590
            | ..|..|                       .|...||......|.|::.|.||:||..|
Mouse   474 S-CQPGTF-----------------------HCGTNLCIFETWRCDGQEDCQDGSDEHGC 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	17/70 (24%)
		LDLa	1448..1483	CDD:238060	12/86 (14%)
		LDLa	1493..1524	CDD:238060	13/32 (41%)
		LDLa	1561..1590	CDD:238060	10/28 (36%)
Lrp3	NP_001019878.1	CUB	64..177	CDD:238001	18/70 (26%)
		LDLa	187..221	CDD:238060	7/44 (16%)
		LDLa	233..270	CDD:238060	17/38 (45%)
		CUB	275..385	CDD:238001	9/109 (8%)
		LDLa	436..472	CDD:238060	15/37 (41%)
		LDLa	475..509	CDD:238060	12/56 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900