DRSC/TRiP Functional Genomics Resources

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Protein Alignment ImpE1 and LRP5

DIOPT Version :9

Sequence 1:NP_001261577.1 Gene:ImpE1 / 45879 FlyBaseID:FBgn0001253 Length:1616 Species:Drosophila melanogaster
Sequence 2:XP_011543331.1 Gene:LRP5 / 4041 HGNCID:6697 Length:1662 Species:Homo sapiens


Alignment Length:203 Identity:59/203 - (29%)
Similarity:79/203 - (38%) Gaps:46/203 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1377 HTVCNRRGVCD--CAAGEEGS-QCS--------------AERTGCSPGTFQCRSSGV-CISWFFV 1423
            |......|.|.  |.|..:|: :||              .|...|||..|.|.:..: ||...:.
Human  1224 HPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWR 1288

  Fly  1424 CDGRADCNDASDEE-CTHNARLNQTCPTESFRCQRSGRCISRAALCDGRRQCPHGEDELGCDGSV 1487
            |||..:|:|.|||| |       ..|....|.|.| |:|:.....|||...|....||..||.  
Human  1289 CDGFPECDDQSDEEGC-------PVCSAAQFPCAR-GQCVDLRLRCDGEADCQDRSDEADCDA-- 1343

  Fly  1488 KGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDE-------------PPHLCGSRALPNLFM 1539
                .|..:.|||.||:|:...:.|::...|.|||||             |.|......:..:.:
Human  1344 ----ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIIL 1404

  Fly  1540 RLIEAGGL 1547
            .|...||:
Human  1405 SLFVMGGV 1412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ImpE1NP_001261577.1 EB 75..131 CDD:279949
LDLa 1404..1437 CDD:238060 14/33 (42%)
LDLa 1448..1483 CDD:238060 12/34 (35%)
LDLa 1493..1524 CDD:238060 12/30 (40%)
LDLa 1561..1590 CDD:238060
LRP5XP_011543331.1 NHL <46..>178 CDD:302697
NHL repeat 74..113 CDD:271320
LY 111..151 CDD:214531
NHL repeat 116..157 CDD:271320
Ldl_recept_b 172..212 CDD:278487
LY 196..238 CDD:214531
FXa_inhibition 308..345 CDD:291342
LY 375..415 CDD:214531
LY 417..459 CDD:214531
LY 460..503 CDD:214531
LY 504..546 CDD:214531
LY 547..580 CDD:214531
FXa_inhibition 614..649 CDD:291342
NHL 694..887 CDD:302697
LY 719..761 CDD:214531
NHL repeat 729..765 CDD:271320
NHL repeat 772..811 CDD:271320
NHL repeat 856..880 CDD:271320
FXa_inhibition 915..950 CDD:291342
LY 979..1018 CDD:214531
LY 1069..1112 CDD:214531
LY 1113..1155 CDD:214531
FXa_inhibition 1226..1262 CDD:291342 7/35 (20%)
Ldl_recept_a 1267..1304 CDD:278486 16/36 (44%)
LDLa 1307..1341 CDD:238060 12/34 (35%)
LDLa 1345..1379 CDD:238060 14/33 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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