Protein Alignment ImpE1 and LRP3

DIOPT Version :9

• Sequence 1: NP_001261577.1
• Gene: ImpE1 / 45879
• FlyBaseID: FBgn0001253
• Length: 1616
• Species: Drosophila melanogaster
• Sequence 2: XP_005259002.1
• Gene: LRP3 / 4037
• HGNCID: 6695
• Length: 785
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 101/443 - (22%)
• Similarity: 121/443 - (27%)
• Gaps: 214/443 - (48%)

  Fly  1304 LMEPAAPVVTTLMPLMTADEPTPEP--VSPAAIPSASLAAIKPGTELRKRVDLGL--EAVSLGLA 1364
            |:.||||             |..|.  :..:|||.|.::|       |..|.:..  :|.|.|.|
Human   105 LLGPAAP-------------PRQEAFRLCGSAIPPAFISA-------RDHVWIFFHSDASSSGQA 149

  Fly  1365 ----------------CSSDR-QCQ----LADPHTVCNRRGVCDCAAGEEGSQCSA---ERTG-- 1403
                            |.:|. :|.    |..|.. ||.  |.:|..|.:...|||   |..|
Human   150 QGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQ-CNT--VDECGDGSDEGNCSAPASEPPGSL 211

  Fly  1404 CSPGTFQCRSSGV----CISWFFVCDGRADCNDASDE---------------------------- 1436
            |..|||.|  ||.    |:.....|||..||.|.|||
Human   212 CPGGTFPC--SGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAA 274

  Fly  1437 ------ECT---------------------------------HNARLNQTCPTES---------- 1452
                  .||                                 ...||.||....|
Human   275 RGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAA 339

  Fly  1453 ---------FRCQRSGR----------------------------------CISRAALCDGRRQC 1474
                     .|.:.:|.                                  |.|....|||...|
Human   340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHC 404

  Fly  1475 PHGEDELGCDGSVKGGNACPEHTFRC--GSGECLPEYEYCNAIVSCKDGSDEPPHLCGSRALPNL 1537
            ..|.||.||.       |||...:.|  |||.|....:.||...||.||:||..  |.| ..|..
Human   405 ASGRDEQGCP-------ACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKN--CFS-CQPGT 459

  Fly  1538 FMRLIEAGGLLGGGRREADAYCPHRCSNGLCRSTAIVCSGRDGCGDGTDEQTC 1590
            |                       .|...||......|.|::.|.||:||..|
Human   460 F-----------------------HCGTNLCIFETWRCDGQEDCQDGSDEHGC 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	17/70 (24%)
		LDLa	1448..1483	CDD:238060	12/87 (14%)
		LDLa	1493..1524	CDD:238060	13/32 (41%)
		LDLa	1561..1590	CDD:238060	10/28 (36%)
LRP3	XP_005259002.1	CUB	43..156	CDD:238001	18/70 (26%)
		LDLa	166..200	CDD:238060	10/36 (28%)
		LDLa	212..249	CDD:238060	17/38 (45%)
		CUB	254..364	CDD:238001	9/109 (8%)
		LDLa	416..452	CDD:238060	15/37 (41%)
		LDLa	455..489	CDD:238060	12/56 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900