DRSC/TRiP Functional Genomics Resources

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Protein Alignment ImpE1 and LRP1

DIOPT Version :10

Sequence 1:NP_524849.2 Gene:ImpE1 / 45879 FlyBaseID:FBgn0001253 Length:1616 Species:Drosophila melanogaster
Sequence 2:NP_002323.2 Gene:LRP1 / 4035 HGNCID:6692 Length:4544 Species:Homo sapiens


Alignment Length:285 Identity:81/285 - (28%)
Similarity:119/285 - (41%) Gaps:62/285 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1344 PGTELRKRVDLGLEA------VSLGLACSSDRQCQLADPHTVCN-----------------RRGV 1385
            ||.: |.|..|...|      :.:...|..:..|:..:..|.||                 ::.:
Human  2689 PGVK-RPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWL 2752

  Fly  1386 C----DCAAG-EEGSQCSAERTGCSPGTFQCRSSGVCISWFFVCDGRADCNDASDEECTHNARLN 1445
            |    ||..| :|.:.|  |...|.|.:|.|..:.||:...::|||..||.|.:||........|
Human  2753 CDGSDDCGDGSDEAAHC--EGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYN 2815

  Fly  1446 QTCPTESFRCQRSGRCISRAALCDGRRQCPHGEDEL-GCDGSVKGGNACPEHTFRCGSGECLPEY 1509
            .||....|.|| :.:||.:..:||..|.|..|.||. .|:..     .|....|||.:|.||...
Human  2816 STCDDREFMCQ-NRQCIPKHFVCDHDRDCADGSDESPECEYP-----TCGPSEFRCANGRCLSSR 2874

  Fly  1510 EY-CNAIVSCKDGSDEP---PHLCGSRALPNLFMRLIEAGGLLGGGRREADAYCPHRCSNGLCRS 1570
            :: |:....|.|.|||.   || |.|:                   ..:.:|.....||:|.|.:
Human  2875 QWECDGENDCHDQSDEAPKNPH-CTSQ-------------------EHKCNASSQFLCSSGRCVA 2919

  Fly  1571 TAIVCSGRDGCGDGTDEQTCSVCRC 1595
            .|::|:|:|.|||.:||:.|.:..|
Human  2920 EALLCNGQDDCGDSSDERGCHINEC 2944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ImpE1NP_524849.2 EB 75..131 CDD:460294
rne <795..981 CDD:236766
LDLa 1404..1437 CDD:238060 13/32 (41%)
LDLa 1448..1483 CDD:238060 13/35 (37%)
LDLa 1493..1524 CDD:238060 11/31 (35%)
LRP1NP_002323.2 LDLa 26..59 CDD:197566
Ldl_recept_a 71..104 CDD:395011
FXa_inhibition 119..148 CDD:464251
FXa_inhibition 158..188 CDD:464251
LY 275..314 CDD:214531
LDL-receptor class B 1 292..334
LY 316..358 CDD:214531
LDL-receptor class B 2 335..378
LY 361..401 CDD:214531
LDL-receptor class B 3 379..422
FXa_inhibition 486..519 CDD:464251
LY 551..593 CDD:214531
LDL-receptor class B 4 571..613
LY 594..633 CDD:214531
LDL-receptor class B 5 614..659
LY 640..689 CDD:214531
LDL-receptor class B 6 660..710
LY <700..733 CDD:214531
LDL-receptor class B 7 711..754
FXa_inhibition 807..842 CDD:464251
LDLa 853..885 CDD:197566
LDLa 895..928 CDD:238060
LDLa 935..967 CDD:197566
LDLa 978..1011 CDD:238060
LDLa 1015..1048 CDD:238060
LDLa 1062..1097 CDD:238060
LDLa 1104..1140 CDD:238060
LDLa 1145..1178 CDD:238060
FXa_inhibition 1185..1221 CDD:464251
LDL-receptor class B 8 1309..1355
Vgb 1310..>1503 CDD:443399
LY 1336..1376 CDD:214531
LDL-receptor class B 9 1356..1398
LY 1380..1423 CDD:214531
LDL-receptor class B 10 1399..1445
LDL-receptor class B 11 1446..1490
LDL-receptor class B 12 1491..1531
LY 1613..1649 CDD:214531
LDL-receptor class B 13 1627..1669
LY 1650..1693 CDD:214531
LDL-receptor class B 14 1670..1713
LY 1697..1734 CDD:214531
LDL-receptor class B 15 1714..1753
LY 1734..1775 CDD:214531
LDL-receptor class B 16 1754..1798
FXa_inhibition 1850..1886 CDD:464251
YncE 1872..2084 CDD:442618
LDL-receptor class B 17 1934..1976
LY 1959..1999 CDD:214531
LDL-receptor class B 18 1977..2019
LDL-receptor class B 19 2020..2063
Ldl_recept_b 2020..2061 CDD:459654
LY 2045..2087 CDD:214531
LDL-receptor class B 20 2064..2107
FXa_inhibition 2159..2194 CDD:464251
LDL-receptor class B 21 2253..2294
LDL-receptor class B 22 2295..2343
LDL-receptor class B 23 2344..2388
Ldl_recept_b 2344..2386 CDD:459654
LY 2370..2411 CDD:214531
LDL-receptor class B 24 2389..2431
LDL-receptor class B 25 2432..2473
FXa_inhibition 2482..2517 CDD:464251
LDLa 2527..2557 CDD:238060
LDLa 2566..2600 CDD:238060
LDLa 2605..2639 CDD:238060
LDLa <2666..2688 CDD:238060
LDLa 2696..2730 CDD:238060 5/33 (15%)
LDLa 2734..2765 CDD:197566 4/30 (13%)
LDLa 2773..2806 CDD:197566 12/32 (38%)
LDLa 2817..2849 CDD:197566 12/32 (38%)
LDLa 2857..2890 CDD:197566 11/32 (34%)
LDLa 2907..2939 CDD:238060 13/31 (42%)
cEGF 2964..2985 CDD:463661
EGF_CA 2982..>3011 CDD:214542
LY 3049..3093 CDD:214531
LDL-receptor class B 26 3069..3113
LY 3094..3136 CDD:214531
LDL-receptor class B 27 3114..3156
LY 3138..3180 CDD:214531
LDL-receptor class B 28 3157..3200
LY 3182..3223 CDD:214531
LDL-receptor class B 29 3201..3243
LY 3224..3264 CDD:214531
LDL-receptor class B 30 3244..3284
FXa_inhibition 3294..3330 CDD:464251
LDLa 3334..3365 CDD:238060
LDLa 3374..3408 CDD:238060
LDLa 3413..3448 CDD:238060
LDLa 3452..3485 CDD:197566
LDLa 3493..3526 CDD:197566
LDLa 3536..3570 CDD:238060
LDLa 3575..3609 CDD:238060
LDLa 3613..3647 CDD:238060
LDLa 3653..3685 CDD:197566
LDLa 3695..3731 CDD:238060
LDLa 3746..3776 CDD:238060
YncE 3862..4064 CDD:442618
LDL-receptor class B 31 3912..3954
Recognition site for proteolytical processing. /evidence=ECO:0000255 3940..3943
LY 3955..3992 CDD:214531
LDL-receptor class B 32 3970..4012
LDL-receptor class B 33 4013..4056
Ldl_recept_b 4013..4054 CDD:459654
LY 4037..4078 CDD:214531
LDL-receptor class B 34 4057..4101
Interaction with MAFB. /evidence=ECO:0000250|UniProtKB:Q91ZX7 4445..4544
NPXY motif 4502..4507
Blue background indicates that the domain is not in the aligned region.

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