DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpE1 and LDLR

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens

Alignment Length:	260	Identity:	86/260 - (33%)
Similarity:	119/260 - (45%)	Gaps:	37/260 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1345 GTELRKRVDLGLEA--VSLGLACS-SDRQCQLADPHTVCNRRGVCD----CAAGEEGSQCSAERT 1402
            |.:||..|.|.|.|  .::|..|. ::.|||  |...: :.:.|||    |..|.:.||.:....
Human     5 GWKLRWTVALLLAAAGTAVGDRCERNEFQCQ--DGKCI-SYKWVCDGSAECQDGSDESQETCLSV 66

  Fly  1403 GCSPGTFQCRSS-GVCISWFFVCDGRADCNDASDEE-CTHNARLNQTCPTESFRCQRSGRCISRA 1465
            .|..|.|.|... ..||..|:.|||:.||::.|||: |.     .:||..:.||| ..|:||||.
Human    67 TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP-----PKTCSQDEFRC-HDGKCISRQ 125

  Fly  1466 ALCDGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDEPPHLCG 1530
            .:||..|.|..|.||..|...     .|...:|:|.|..|:|:...|:....|:|||||.|..|
Human   126 FVCDSDRDCLDGSDEASCPVL-----TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC- 184

  Fly  1531 SRALPNLFMRLIEAGGLLGGGRREADAYCPHRCSNGLCRSTAIVCSGRDGCGDGTDEQTCSVCRC 1595
             |.|           .:..|......|:..| |.:|.|..::..|.|...|.|.:||:.|:|..|
Human   185 -RGL-----------YVFQGDSSPCSAFEFH-CLSGECIHSSWRCDGGPDCKDKSDEENCAVATC 236

Fly 1596 1595
Human 237 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	14/33 (42%)
		LDLa	1448..1483	CDD:238060	16/34 (47%)
		LDLa	1493..1524	CDD:238060	11/30 (37%)
		LDLa	1561..1590	CDD:238060	10/28 (36%)
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486	10/35 (29%)
		Ldl_recept_a	66..104	CDD:278486	15/37 (41%)
		Ldl_recept_a	107..143	CDD:278486	17/36 (47%)
		Ldl_recept_a	147..179	CDD:278486	11/31 (35%)
		Ldl_recept_a	195..231	CDD:278486	11/36 (31%)
		Ldl_recept_a	235..270	CDD:278486	1/2 (50%)
		LDLa	278..308	CDD:294076
		FXa_inhibition	318..>346	CDD:291342
		EGF_CA	354..388	CDD:214542
		LDL-receptor class B 1	397..438
		LY	419..457	CDD:214531
		LDL-receptor class B 2	439..485
		Ldl_recept_b	439..482	CDD:278487
		LDL-receptor class B 3	486..528
		Ldl_recept_b	487..525	CDD:278487
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:278487
		LY	553..595	CDD:214531
		LDL-receptor class B 5	573..615
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..655	CDD:278487
		FXa_inhibition	671..711	CDD:291342
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900