DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpE1 and Ldlr

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_786938.2	Gene:	Ldlr / 300438	RGDID:	2998	Length:	879	Species:	Rattus norvegicus

Alignment Length:	264	Identity:	84/264 - (31%)
Similarity:	112/264 - (42%)	Gaps:	46/264 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1347 ELRKRVDLGLEAVSLGLA----CSSDR-QCQLADPHTVCNRRGVCD----CAAGEEGSQCSAERT 1402
            :|..|..:.|...:.|:|    |..:. ||:  |...:.: :.|||    |..|.:.|..:....
  Rat     5 DLMLRWAIALLLAAAGVAAEDSCGKNEFQCR--DGKCIVS-KWVCDGSRECPDGSDESPETCMSV 66

  Fly  1403 GCSPGTFQC--RSSGVCISWFFVCDGRADCNDASDE-ECTHNARLNQTCPTESFRCQRSGRCISR 1464
            .|..|.|.|  |.|. ||...:.||||.||.:.||| :|:     .:||..:.|||| .|:||||
  Rat    67 TCRSGEFSCGGRVSR-CIPDSWRCDGRTDCENGSDELDCS-----PKTCSLDEFRCQ-DGKCISR 124

  Fly  1465 AALCDGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDEPPHLC 1529
            ..:||....|..|.||..|..:..|    |.| |||.|..|:|....|:....|.|||||.|..|
  Rat   125 QFVCDQDWDCLDGSDEAHCAATTCG----PAH-FRCNSSSCIPSLWACDGDRDCDDGSDEWPQNC 184

  Fly  1530 GSRALPNLFMRLIEAGGLLGGGRREADAYC---PHRCSNGLCRSTAIVCSGRDGCGDGTDEQTCS 1591
            |.|                ........:.|   ...|.:..|...:.||.|...|.|.:||:.|:
  Rat   185 GGR----------------DTAAEVVSSPCSSLEFHCGSSECIHRSWVCDGAADCKDKSDEENCA 233

  Fly  1592 VCRC 1595
            |..|
  Rat   234 VTTC 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	17/35 (49%)
		LDLa	1448..1483	CDD:238060	16/34 (47%)
		LDLa	1493..1524	CDD:238060	13/30 (43%)
		LDLa	1561..1590	CDD:238060	9/28 (32%)
Ldlr	NP_786938.2	Ldl_recept_a	25..58	CDD:395011	9/35 (26%)
		Ldl_recept_a	66..104	CDD:395011	17/38 (45%)
		Ldl_recept_a	107..143	CDD:395011	17/36 (47%)
		Ldl_recept_a	196..232	CDD:395011	10/35 (29%)
		Ldl_recept_a	235..271	CDD:395011	1/3 (33%)
		Ldl_recept_a	279..309	CDD:395011
		FXa_inhibition	319..353	CDD:405372
		EGF_CA	355..389	CDD:214542
		LDL-receptor class B 1	398..439
		NHL	<435..628	CDD:302697
		NHL repeat	435..469	CDD:271320
		LDL-receptor class B 2	440..485
		NHL repeat	476..514	CDD:271320
		LDL-receptor class B 3	486..528
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:395012
		NHL repeat	555..600	CDD:271320
		LDL-receptor class B 5	573..615
		NHL repeat	606..628	CDD:271320
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..655	CDD:395012
		FXa_inhibition	674..711	CDD:405372
		Clustered O-linked oligosaccharides	717..788
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..797
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250\|UniProtKB:P01130	830..879
		NPXY motif. /evidence=ECO:0000250\|UniProtKB:P01130	842..847
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900