DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpE1 and LRP10

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	XP_005267567.1	Gene:	LRP10 / 26020	HGNCID:	14553	Length:	721	Species:	Homo sapiens

Alignment Length:	498	Identity:	103/498 - (20%)
Similarity:	130/498 - (26%)	Gaps:	249/498 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly  1263 NHIEEEEPAA---------HAIPHEEATPNPAD----IVEITTQTM------LGLA---SRVTLM 1305
            ||..|:.||.         ..:..:..| :||:    |:....||:      |.||   .|:||.
Human    25 NHACEDPPAVLLEVQGTLQRPLVRDSRT-SPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLR 88

  Fly  1306 EPAAPVVTTLMPLMTADEPTPEPVSPAAIPSASLAAIKPGTELRKRVDLGLEAVSLGLACSSDRQ 1370
            .|       |.||::..|..|   ||..:|..::.........|..:..|.        ..|..|
Human    89 SP-------LQPLISLCEAPP---SPLQLPGGNVTITYSYAGARAPMGQGF--------LLSYSQ 135

  Fly  1371 CQLADPHTVCNRRGVCDCAAGEEGSQCSAERTGCSPGTFQCRSSGVCISWFFVCDGRADCNDASD 1435
            ..|                   .|:  ||:...|....|||.:.. |:|....|||...|.|.||
Human   136 APL-------------------HGA--SADWLMCLQEEFQCLNHR-CVSAVQRCDGVDACGDGSD 178

  Fly  1436 E-------------------EC----------------THNARLN--QTC--------------- 1448
            |                   .|                ||.|.::  |:|
Human   179 EAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVR 243

  Fly  1449 -------------------PTESFRCQRS------------------------------------ 1458
                               |.||.|..||
Human   244 FTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNA 308

  Fly  1459 ----------------------------GRCISRAALCDGRRQCPHGEDELGCDGSVKGGNACPE 1495
                                        .||.|.|..|||...|..|.||..|.|       ||.
Human   309 TYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPG-------CPP 366

  Fly  1496 HTFRCGSG------ECLPEYEYCNAIVSCKDGSDEPPHLCGSRALPNLFMRLIEAGGLLGGGRRE 1554
            ..|.||:.      .|....:.||....|.||:||                           ||
Human   367 GHFPCGAAGTSGATACYLPADRCNYQTFCADGADE---------------------------RR- 403

  Fly  1555 ADAYCPH------RCSNGLCRSTAIVCSGRDGCGDGTDEQTCS 1591
                |.|      ||.:..|.....||.|:..|.||:||..||
Human   404 ----CRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	14/51 (27%)
		LDLa	1448..1483	CDD:238060	18/132 (14%)
		LDLa	1493..1524	CDD:238060	11/36 (31%)
		LDLa	1561..1590	CDD:238060	12/34 (35%)
LRP10	XP_005267567.1	CUB	34..134	CDD:238001	24/118 (20%)
		LDLa	148..182	CDD:238060	14/34 (41%)
		CUB	200..310	CDD:238001	12/109 (11%)
		LDLa	<338..361	CDD:238060	11/22 (50%)
		LDLa	407..441	CDD:238060	11/33 (33%)
		PRK04654	<581..683	CDD:135173
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900