DRSC/TRiP Functional Genomics Resources

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Protein Alignment ImpE1 and Lrp4

DIOPT Version :9

Sequence 1:NP_001261577.1 Gene:ImpE1 / 45879 FlyBaseID:FBgn0001253 Length:1616 Species:Drosophila melanogaster
Sequence 2:NP_766256.3 Gene:Lrp4 / 228357 MGIID:2442252 Length:1905 Species:Mus musculus


Alignment Length:281 Identity:86/281 - (30%)
Similarity:113/281 - (40%) Gaps:56/281 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  1358 AVSLG-LAC----SSDRQCQLADPHTVC--NRRGVCDCA-----------AGEEGSQCSAERTGC 1404
            |:.|| |.|    :|..:|.....|..|  :..|.|.|.           .|:...:.......|
Mouse     7 ALLLGALLCAHGIASSLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCTLPTC 71

  Fly  1405 SPGTFQCRSSGVCISWFFVCDGRADCNDASDE-ECTHNARLNQTCPTESFRCQRSGRCISRAALC 1468
            ||..|.| .:|.||...:||||..||.|.||| :|.     .:.|..:.|.|| :|.||.....|
Mouse    72 SPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDEQDCP-----PRECEEDEFPCQ-NGYCIRSLWHC 129

  Fly  1469 DGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDE--------- 1524
            ||...|....|| .||     ...|.:..|||..|.|:.|:.||:....|||||||         
Mouse   130 DGDNDCGDNSDE-QCD-----MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPS 188

  Fly  1525 PPHLCGSRALPNLFMRLI------EAGGLLGGGRREAD--AYCPHR-----CSNGLCRSTAIVCS 1576
            ||  |........:.|.|      :.....|....|:|  ::.|.|     |.:|||.::...|.
Mouse   189 PP--CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINSGWRCD 251

  Fly  1577 GRDGCGDGTDEQTCSVCRCPA 1597
            |...|.|.:||:.|:...|.|
Mouse   252 GDADCDDQSDERNCTTSMCTA 272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ImpE1NP_001261577.1 EB 75..131 CDD:279949
LDLa 1404..1437 CDD:238060 18/33 (55%)
LDLa 1448..1483 CDD:238060 13/34 (38%)
LDLa 1493..1524 CDD:238060 14/30 (47%)
LDLa 1561..1590 CDD:238060 11/33 (33%)
Lrp4NP_766256.3 LDLa 27..66 CDD:238060 6/38 (16%)
Ldl_recept_a 70..105 CDD:278486 18/35 (51%)
LDLa 110..142 CDD:238060 13/33 (39%)
LDLa 148..182 CDD:238060 16/33 (48%)
LDLa 231..265 CDD:238060 11/33 (33%)
LDLa 270..304 CDD:238060 2/3 (67%)
LDLa 311..343 CDD:197566
FXa_inhibition 358..393 CDD:291342
EGF_CA 395..434 CDD:214542
NHL <471..622 CDD:302697
NHL repeat 471..507 CDD:271320
LDL-receptor class B 1 480..522
LY 505..545 CDD:214531
NHL repeat 510..550 CDD:271320
LDL-receptor class B 2 523..565
NHL repeat 555..589 CDD:271320
LDL-receptor class B 3 566..609
LY 590..632 CDD:214531
NHL repeat 598..622 CDD:271320
LDL-receptor class B 4 610..652
LY 633..673 CDD:214531
LDL-receptor class B 5 653..693
FXa_inhibition 702..>729 CDD:291342
LY 766..806 CDD:214531
LDL-receptor class B 6 785..827
LY 808..850 CDD:214531
LDL-receptor class B 7 828..870
LDL-receptor class B 8 871..914
Ldl_recept_b 871..911 CDD:278487
LY 895..937 CDD:214531
LDL-receptor class B 9 915..956
LY 938..979 CDD:214531
LDL-receptor class B 10 957..998
FXa_inhibition 1006..1043 CDD:291342
NHL <1085..1277 CDD:302697
NHL repeat 1085..1123 CDD:271320
LDL-receptor class B 11 1093..1135
NHL repeat 1128..1161 CDD:271320
LDL-receptor class B 12 1136..1178
NHL repeat 1166..1203 CDD:271320
LDL-receptor class B 13 1179..1222
NHL repeat 1212..1244 CDD:271320
LDL-receptor class B 14 1223..1263
NHL repeat 1253..1277 CDD:271320
LDL-receptor class B 15 1264..1306
FXa_inhibition 1313..1348 CDD:291342
LY 1379..1418 CDD:214531
LDL-receptor class B 16 1397..1439
LY 1420..1460 CDD:214531
LDL-receptor class B 17 1440..1482
LDL-receptor class B 18 1483..1526
Ldl_recept_b 1483..1523 CDD:278487
LY 1507..1547 CDD:214531
LDL-receptor class B 19 1527..1568
LY 1549..1589 CDD:214531
LDL-receptor class B 20 1569..1610
FXa_inhibition 1617..1648 CDD:291342
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1696
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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