DRSC/TRiP Functional Genomics Resources

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Protein Alignment ImpE1 and Lrp4

DIOPT Version :10

Sequence 1:NP_524849.2 Gene:ImpE1 / 45879 FlyBaseID:FBgn0001253 Length:1616 Species:Drosophila melanogaster
Sequence 2:NP_766256.3 Gene:Lrp4 / 228357 MGIID:2442252 Length:1905 Species:Mus musculus


Alignment Length:281 Identity:86/281 - (30%)
Similarity:113/281 - (40%) Gaps:56/281 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  1358 AVSLG-LAC----SSDRQCQLADPHTVC--NRRGVCDCA-----------AGEEGSQCSAERTGC 1404
            |:.|| |.|    :|..:|.....|..|  :..|.|.|.           .|:...:.......|
Mouse     7 ALLLGALLCAHGIASSLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCTLPTC 71

  Fly  1405 SPGTFQCRSSGVCISWFFVCDGRADCNDASDE-ECTHNARLNQTCPTESFRCQRSGRCISRAALC 1468
            ||..|.| .:|.||...:||||..||.|.||| :|.     .:.|..:.|.|| :|.||.....|
Mouse    72 SPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDEQDCP-----PRECEEDEFPCQ-NGYCIRSLWHC 129

  Fly  1469 DGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDE--------- 1524
            ||...|....|| .||     ...|.:..|||..|.|:.|:.||:....|||||||         
Mouse   130 DGDNDCGDNSDE-QCD-----MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPS 188

  Fly  1525 PPHLCGSRALPNLFMRLI------EAGGLLGGGRREAD--AYCPHR-----CSNGLCRSTAIVCS 1576
            ||  |........:.|.|      :.....|....|:|  ::.|.|     |.:|||.::...|.
Mouse   189 PP--CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINSGWRCD 251

  Fly  1577 GRDGCGDGTDEQTCSVCRCPA 1597
            |...|.|.:||:.|:...|.|
Mouse   252 GDADCDDQSDERNCTTSMCTA 272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ImpE1NP_524849.2 EB 75..131 CDD:460294
rne <795..981 CDD:236766
LDLa 1404..1437 CDD:238060 18/33 (55%)
LDLa 1448..1483 CDD:238060 13/34 (38%)
LDLa 1493..1524 CDD:238060 14/30 (47%)
Lrp4NP_766256.3 LDLa 27..66 CDD:238060 6/38 (16%)
Ldl_recept_a 70..105 CDD:395011 18/35 (51%)
LDLa 110..142 CDD:238060 13/33 (39%)
LDLa 148..182 CDD:238060 16/33 (48%)
LDLa 231..265 CDD:238060 11/33 (33%)
LDLa 270..304 CDD:238060 2/3 (67%)
LDLa 311..343 CDD:197566
FXa_inhibition 358..393 CDD:464251
EGF_CA 395..434 CDD:214542
LY 460..502 CDD:214531
LDL-receptor class B 1 480..522
LY 505..545 CDD:214531
LDL-receptor class B 2 523..565
LDL-receptor class B 3 566..609
Ldl_recept_b 566..607 CDD:459654
LY 590..632 CDD:214531
LDL-receptor class B 4 610..652
LY 633..673 CDD:214531
LDL-receptor class B 5 653..693
FXa_inhibition 702..>729 CDD:464251
YncE 749..982 CDD:442618
LDL-receptor class B 6 785..827
LY 808..850 CDD:214531
LDL-receptor class B 7 828..870
LDL-receptor class B 8 871..914
Ldl_recept_b 871..912 CDD:459654
LY 895..937 CDD:214531
LDL-receptor class B 9 915..956
LDL-receptor class B 10 957..998
FXa_inhibition 1006..1043 CDD:464251
NHL <1085..1277 CDD:302697
NHL repeat 1085..1123 CDD:271320
LDL-receptor class B 11 1093..1135
NHL repeat 1128..1161 CDD:271320
LDL-receptor class B 12 1136..1178
NHL repeat 1166..1203 CDD:271320
LDL-receptor class B 13 1179..1222
Ldl_recept_b 1179..1219 CDD:459654
NHL repeat 1212..1244 CDD:271320
LDL-receptor class B 14 1223..1263
NHL repeat 1253..1277 CDD:271320
LDL-receptor class B 15 1264..1306
FXa_inhibition 1313..1348 CDD:464251
Vgb 1359..1583 CDD:443399
LDL-receptor class B 16 1397..1439
LDL-receptor class B 17 1440..1482
LDL-receptor class B 18 1483..1526
Ldl_recept_b 1483..1524 CDD:459654
LY 1507..1547 CDD:214531
LDL-receptor class B 19 1527..1568
LDL-receptor class B 20 1569..1610
FXa_inhibition 1617..1648 CDD:464251
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1696
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
Blue background indicates that the domain is not in the aligned region.

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