DRSC/TRiP Functional Genomics Resources

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Protein Alignment ImpE1 and Vldlr

DIOPT Version :9

Sequence 1:NP_001261577.1 Gene:ImpE1 / 45879 FlyBaseID:FBgn0001253 Length:1616 Species:Drosophila melanogaster
Sequence 2:NP_038731.2 Gene:Vldlr / 22359 MGIID:98935 Length:873 Species:Mus musculus


Alignment Length:296 Identity:83/296 - (28%)
Similarity:113/296 - (38%) Gaps:76/296 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1359 VSLGLACSSDRQC------------QLADPHTVCNRRGVC-----------DCAAGEEGS----- 1395
            ::|...|..|..|            ..|:...|| :.|.|           ||..|.:.|     
Mouse    46 ITLLWKCDGDEDCADGSDEKNCVKKTCAESDFVC-KNGQCVPNRWQCDGDPDCEDGSDESPEQCH 109

  Fly  1396 --QCSAERTGCSPGTFQCRSSGVCISWFFVCDGRADCNDASDEE-CTHNARLNQTCPTESFRCQR 1457
              .|......|...:.||    :.:||  .|||..||::..||| |.     |.||..:.|.|. 
Mouse   110 MRTCRINEISCGARSTQC----IPVSW--RCDGENDCDNGEDEENCG-----NITCSADEFTCS- 162

  Fly  1458 SGRCISRAALCDGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGS 1522
            ||||:||..:|:|:..|..|.|||.|     ....|..|.|:|.:..|:|....|:....|.|.|
Mouse   163 SGRCVSRNFVCNGQDDCDDGSDELDC-----APPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQS 222

  Fly  1523 DEPPHLCGSRALPNLFMRLIEAGGLLGGG-------RREAD---------AYCPHR--------C 1563
            ||....||.:  |.:..:...:....|.|       |.:.|         ..||.|        |
Mouse   223 DESLEQCGRQ--PVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFEC 285

  Fly  1564 SNGLCRSTAIVCSGRDGCGDGTDEQTC-SVCRCPAP 1598
            .:|.|...:..|:|...|.||:||..| :|.:|..|
Mouse   286 EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ImpE1NP_001261577.1 EB 75..131 CDD:279949
LDLa 1404..1437 CDD:238060 11/32 (34%)
LDLa 1448..1483 CDD:238060 16/34 (47%)
LDLa 1493..1524 CDD:238060 10/30 (33%)
LDLa 1561..1590 CDD:238060 11/36 (31%)
VldlrNP_038731.2 LDLa 33..67 CDD:238060 4/20 (20%)
LDLa 71..103 CDD:197566 8/32 (25%)
Ldl_recept_a 111..149 CDD:365841 14/43 (33%)
Ldl_recept_a 153..188 CDD:365841 17/35 (49%)
Ldl_recept_a 192..224 CDD:365841 10/31 (32%)
Ldl_recept_a 237..273 CDD:365841 4/35 (11%)
Ldl_recept_a 276..312 CDD:365841 11/35 (31%)
Ldl_recept_a 320..350 CDD:365841 1/2 (50%)
FXa_inhibition 360..394 CDD:373209
EGF_CA 396..426 CDD:214542
LDL-receptor class B 1 439..480
LY 461..499 CDD:214531
LDL-receptor class B 2 481..524
Ldl_recept_b 481..521 CDD:278487
LY 508..547 CDD:214531
LDL-receptor class B 3 525..567
LDL-receptor class B 4 568..611
Ldl_recept_b 568..608 CDD:278487
LY 592..634 CDD:214531
LDL-receptor class B 5 612..654
LDL-receptor class B 6 655..697
Ldl_recept_b 655..694 CDD:278487
FXa_inhibition 711..749 CDD:373209
Clustered O-linked oligosaccharides 751..790
Endocytosis signal. /evidence=ECO:0000255 832..837
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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