DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpE1 and Sorl1

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_035566.2	Gene:	Sorl1 / 20660	MGIID:	1202296	Length:	2215	Species:	Mus musculus

Alignment Length:	454	Identity:	119/454 - (26%)
Similarity:	163/454 - (35%)	Gaps:	133/454 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1242 QSESLILESTTNIDGLQELDNNHIEEEEPAAHAIPHEE-------------ATPNPADIVEITTQ 1293
            |..|:||:|..:                |.|.|:...|             |:.:....|||...
Mouse   951 QQRSVILDSLPH----------------PYAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILAS 999

  Fly  1294 TMLGLASRVTLME-------PAAPVVTTLMPLMTADEP----TPEPVSPAAIPSASLAAIKPGTE 1347
            .:.||.......:       ...|...:|:.|..|:..    .||.|:.:.:||..|....|...
Mouse  1000 QLTGLMDMKVFYKGKNAGSNACVPQPCSLLCLPKANNSKSCRCPEGVASSVLPSGDLMCDCPQGY 1064

  Fly  1348 LRK----------------RVDLGLEAVSLGLACSSDRQC-QLAD----PHTVCN--------RR 1383
            .||                |...| ..::....|..|..| .::|    |.|||:        ..
Mouse  1065 QRKNNTCVKEENTCLRNQYRCSNG-NCINSIWWCDFDNDCGDMSDERNCPTTVCDADTQFRCQES 1128

  Fly  1384 GVC-----------DCAAGEEGSQCSAERTGCSPGTFQCRSSGVCISWFFVCDGRADCNDASDE- 1436
            |.|           ||....:.|.|  |...|....|.| |||:||...:||||..||.|.|||
Mouse  1129 GTCIPLSYKCDLEDDCGDNSDESHC--EMHQCRSDEFNC-SSGMCIRSSWVCDGDNDCRDWSDEA 1190

  Fly  1437 ECTHNARLNQTCPTESFRCQRSGRCISRAALCDGRRQCPHGEDE--LGCDGSVKGGNACPEHTFR 1499
            .||   .:..||...:|:| .:|.||.:...|||...|..|.||  :.|:....|        |.
Mouse  1191 NCT---AIYHTCEASNFQC-HNGHCIPQRWACDGDADCQDGSDEDPVSCEKKCNG--------FH 1243

  Fly  1500 CGSGECLPEYEYCNAIVSCKDGSDEP----------PHLCGSRALPNLFMRLIEAGGLL----GG 1550
            |.:|.|:|..::|:.:..|.|||||.          ..:|.:|. ..||..:: ..|::    |.
Mouse  1244 CPNGTCIPSSKHCDGLRDCPDGSDEQHCEPFCTRFMDFVCKNRQ-QCLFHSMV-CDGIVQCRDGS 1306

  Fly  1551 GRREADAYCPH-------------RCSNGLCRSTAIVCSGRDGCGDGTDEQTCSVCRCPAPTAA 1601
            ....|.|.|..             :|.||:|.|....|.|.|.|||.:||     ..|..||.|
Mouse  1307 DEDAAFAGCSQDPEFHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE-----ANCENPTEA 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	18/33 (55%)
		LDLa	1448..1483	CDD:238060	13/36 (36%)
		LDLa	1493..1524	CDD:238060	10/30 (33%)
		LDLa	1561..1590	CDD:238060	13/41 (32%)
Sorl1	NP_035566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..84
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		Sortilin_C	588..753	CDD:292523
		LY	780..821	CDD:214531
		LDL-receptor class B 1	800..843
		LY	824..866	CDD:214531
		LDL-receptor class B 2	844..887
		LY	868..910	CDD:214531
		LDL-receptor class B 3	888..932
		Ldl_recept_b	890..929	CDD:278487
		LY	913..953	CDD:214531	1/1 (100%)
		LDL-receptor class B 4	933..972		8/36 (22%)
		LDL-receptor class B 5	973..1013		6/39 (15%)
		LDLa	1078..1112	CDD:238060	6/34 (18%)
		LDLa	1117..1153	CDD:238060	6/35 (17%)
		Ldl_recept_a	1157..1192	CDD:278486	18/35 (51%)
		Ldl_recept_a	1198..1230	CDD:278486	12/32 (38%)
		LDLa	1240..1271	CDD:238060	13/38 (34%)
		LDLa	1281..1308	CDD:197566	6/28 (21%)
		LDLa	1325..1359	CDD:238060	13/38 (34%)
		LDLa	1373..1403	CDD:238060
		LDLa	1419..1453	CDD:238060
		LDLa	1471..1506	CDD:238060
		LDLa	1514..1549	CDD:238060
		FN3	1557..1630	CDD:238020
		FN3	1651..1742	CDD:238020
		FN3	1752..1831	CDD:238020
		FN3	1935..2022	CDD:238020
		FN3	2026..2113	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250\|UniProtKB:Q92673	2162..2165
		Endocytosis signal. /evidence=ECO:0000255	2173..2178
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250\|UniProtKB:Q92673	2191..2215
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250\|UniProtKB:Q92673	2202..2215
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250\|UniProtKB:Q92673	2209..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900