DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpE1 and EGF

DIOPT Version :9

Sequence 1:	NP_001261577.1	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	XP_016863334.1	Gene:	EGF / 1950	HGNCID:	3229	Length:	1223	Species:	Homo sapiens

Alignment Length:	232	Identity:	52/232 - (22%)
Similarity:	78/232 - (33%)	Gaps:	81/232 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1329 VSPAAIPSASLAAIKPGTELRKRVDLGLEAVSLGLACSSDRQCQLADPHTVCN---RRGVCDCAA 1390
            |.|.|.|.|.....:|..:|.|        :..| .|||          |||.   :..:|.||.
Human   306 VHPLAQPKAEDDTWEPEQKLCK--------LRKG-NCSS----------TVCGQDLQSHLCMCAE 351

  Fly  1391 G----------EEGSQCSAERTGC------SPGTFQCRSSGVC-ISWFFVCDGRADCNDASDEEC 1438
            |          |:.::|:....||      :||::.|    .| :.:..:.||:
Human   352 GYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYC----TCPVGFVLLPDGK----------- 401

  Fly  1439 THNARLNQ--TCPTESFRCQRSGRCISRAALCDGRRQCPHGEDELGCDGSVKGGNACPEH----- 1496
                |.:|  :||.....|.......|...||    .||.| ..|..||....|.:.|::
Human   402 ----RCHQLVSCPRNVSECSHDCVLTSEGPLC----FCPEG-SVLERDGKTCSGCSSPDNGGCSQ 457

  Fly  1497 --------TFRCGSGECLPEYEYCNAIVSCKDGSDEP 1525
                    ::.|   :|.|.|:......||.....:|
Human   458 LCVPLSPVSWEC---DCFPGYDLQLDEKSCAASGPQP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_001261577.1	EB	75..131	CDD:279949
		LDLa	1404..1437	CDD:238060	7/39 (18%)
		LDLa	1448..1483	CDD:238060	10/34 (29%)
		LDLa	1493..1524	CDD:238060	7/43 (16%)
		LDLa	1561..1590	CDD:238060
EGF	XP_016863334.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900