DRSC/TRiP Functional Genomics Resources

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Protein Alignment ImpE1 and Lrp6

DIOPT Version :10

Sequence 1:NP_524849.2 Gene:ImpE1 / 45879 FlyBaseID:FBgn0001253 Length:1616 Species:Drosophila melanogaster
Sequence 2:NP_032540.2 Gene:Lrp6 / 16974 MGIID:1298218 Length:1613 Species:Mus musculus


Alignment Length:394 Identity:89/394 - (22%)
Similarity:137/394 - (34%) Gaps:132/394 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1227 FDLTDHSDVNRFNELQSESLILE----------STTNIDGLQELDNNHI------EEEEPAAHAI 1275
            |::..:|..|:..|:|...|.::          ..||:..:..||...:      |::.|.|..:
Mouse  1000 FNVVANSVANQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVV 1064

  Fly  1276 PHE----------EATPN-------------------------------------PADIVEITTQ 1293
            ..|          |.:|.                                     .:|:..|.:.
Mouse  1065 NPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSKLGKLFWADSDLRRIESS 1129

  Fly  1294 TMLGLASRVTLMEPAAPVVTTLMPLMTADEPTPEPVSPAAIPSASLAAIKPGTELRKRVDL-GLE 1357
            .:.| |:|:.|                .|....:||......: .|..|....::.:::|: |.|
Mouse  1130 DLSG-ANRIVL----------------EDSNILQPVGLTVFEN-WLYWIDKQQQMIEKIDMTGRE 1176

  Fly  1358 AVSLGLACSSDRQCQLADPHTV------------CNR-RGVCD--C-AAGEEGSQCS-------- 1398
                |......|..||:|.|.|            |.: .|.|.  | ..|:..::||        
Mouse  1177 ----GRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLL 1237

  Fly  1399 ------AERTGCSPGTFQCRSSGV-CISWFFVCDGRADCNDASDEECTHNARLN-QTCPTESFRC 1455
                  .|...|||..|.|.:..: ||...:.|||..:|.|.|||       || ..|....|:|
Mouse  1238 QDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDE-------LNCPVCSESQFQC 1295

  Fly  1456 QRSGRCISRAALCDGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKD 1520
             .||:||..|..|:|...|....||..|:      ..|....|||.:|:|:.:::.|:..|.|.|
Mouse  1296 -ASGQCIDGALRCNGDANCQDKSDEKNCE------VLCLIDQFRCANGQCVGKHKKCDHSVDCSD 1353

  Fly  1521 GSDE 1524
            .|||
Mouse  1354 RSDE 1357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ImpE1NP_524849.2 EB 75..131 CDD:460294
rne <795..981 CDD:236766
LDLa 1404..1437 CDD:238060 14/33 (42%)
LDLa 1448..1483 CDD:238060 13/34 (38%)
LDLa 1493..1524 CDD:238060 11/30 (37%)
Lrp6NP_032540.2 YncE 1..204 CDD:442618
Beta-propeller 1 20..275
LY 89..127 CDD:214531
Ldl_recept_b 150..191 CDD:459654
LY 175..216 CDD:214531
LY 217..251 CDD:214531
LDL-receptor class B 5 236..277
FXa_inhibition 286..323 CDD:464251
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
Ldl_recept_b 458..499 CDD:459654
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:464251
Beta-propeller 3 631..890
YncE <654..813 CDD:442618
LY 697..739 CDD:214531
LY 827..866 CDD:214531
FXa_inhibition 893..929 CDD:464251
Beta-propeller 4 933..1202 37/223 (17%)
LY 958..998 CDD:214531
YncE <968..1075 CDD:442618 14/74 (19%)
Ldl_recept_b 1069..1110 CDD:459654 2/40 (5%)
LY 1094..1136 CDD:214531 4/42 (10%)
FXa_inhibition 1207..1243 CDD:464251 7/35 (20%)
LDLa 1249..1285 CDD:238060 16/42 (38%)
LDLa 1288..1322 CDD:238060 13/34 (38%)
LDLa 1326..1360 CDD:238060 13/32 (41%)
PPPSP motif A 1487..1493
PPPSP motif B 1527..1534
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1613
PPPSP motif C 1568..1575
PPPSP motif D 1588..1593
PPPSP motif E 1603..1610
Blue background indicates that the domain is not in the aligned region.

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