Protein Alignment ImpE1 and Ldlr

DIOPT Version :10

• Sequence 1: NP_524849.2
• Gene: ImpE1 / 45879
• FlyBaseID: FBgn0001253
• Length: 1616
• Species: Drosophila melanogaster
• Sequence 2: NP_034830.2
• Gene: Ldlr / 16835
• MGIID: 96765
• Length: 862
• Species: Mus musculus
• Alignment Length: 264
• Identity: 84/264 - (31%)
• Similarity: 116/264 - (43%)
• Gaps: 46/264 - (17%)

  Fly  1347 ELRKRVDLGLEAVSLGLA----CS-SDRQCQLADPHTVCNRRGVCD----CAAGEEGSQCSAERT 1402
            :|.:|..:.|...:.|:|    || ::.||:  |...:.: :.|||    |..|.:.|..:....
Mouse     5 DLMRRWVIALLLAAAGVAAEDSCSRNEFQCR--DGKCIAS-KWVCDGSPECPDGSDESPETCMSV 66

  Fly  1403 GCSPGTFQC--RSSGVCISWFFVCDGRADCNDASDEE-CTHNARLNQTCPTESFRCQRSGRCISR 1464
            .|....|.|  |.|. ||...:.|||:.||.:.|||: |.     .:||..:.|||| .|:|||.
Mouse    67 TCQSNQFSCGGRVSR-CIPDSWRCDGQVDCENDSDEQGCP-----PKTCSQDDFRCQ-DGKCISP 124

  Fly  1465 AALCDGRRQCPHGEDELGCDGSVKGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDEPPHLC 1529
            ..:|||.|.|..|.||..|..:..|    |.| |||.|..|:|....|:..|.|.|||||.|..|
Mouse   125 QFVCDGDRDCLDGSDEAHCQATTCG----PAH-FRCNSSICIPSLWACDGDVDCVDGSDEWPQNC 184

  Fly  1530 GSRALPNLFMRLIEAGGLLGGGRREADAYC---PHRCSNGLCRSTAIVCSGRDGCGDGTDEQTCS 1591
            ..|...:                :...:.|   ...|.:..|...:.||.|...|.|.:||:.|:
Mouse   185 QGRDTAS----------------KGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCA 233

  Fly  1592 VCRC 1595
            |..|
Mouse   234 VATC 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_524849.2	EB	75..131	CDD:460294
		rne	<795..981	CDD:236766
		LDLa	1404..1437	CDD:238060	14/34 (41%)
		LDLa	1448..1483	CDD:238060	17/34 (50%)
		LDLa	1493..1524	CDD:238060	14/30 (47%)
Ldlr	NP_034830.2	Ldl_recept_a	25..58	CDD:395011	10/35 (29%)
		Ldl_recept_a	66..104	CDD:395011	15/38 (39%)
		Ldl_recept_a	107..143	CDD:395011	18/36 (50%)
		Ldl_recept_a	146..184	CDD:395011	18/42 (43%)
		Ldl_recept_a	196..232	CDD:395011	10/35 (29%)
		Ldl_recept_a	236..271	CDD:395011	1/2 (50%)
		Ldl_recept_a	279..309	CDD:395011
		FXa_inhibition	319..>347	CDD:464251
		EGF_CA	355..389	CDD:214542
		LDL-receptor class B 1	398..439
		LY	420..458	CDD:214531
		LDL-receptor class B 2	440..485
		Ldl_recept_b	440..483	CDD:459654
		LDL-receptor class B 3	486..528
		Ldl_recept_b	486..526	CDD:459654
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:459654
		LY	553..595	CDD:214531
		LDL-receptor class B 5	573..615
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..656	CDD:459654
		FXa_inhibition	675..712	CDD:464251
		Clustered O-linked oligosaccharides	722..770
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	730..761
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130	813..862
		NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130	825..830