DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpE1 and Lrp2

DIOPT Version :10

Sequence 1:	NP_524849.2	Gene:	ImpE1 / 45879	FlyBaseID:	FBgn0001253	Length:	1616	Species:	Drosophila melanogaster
Sequence 2:	NP_001074557.1	Gene:	Lrp2 / 14725	MGIID:	95794	Length:	4660	Species:	Mus musculus

Alignment Length:	306	Identity:	80/306 - (26%)
Similarity:	101/306 - (33%)	Gaps:	107/306 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1365 CSSDRQC---------------------QLADPHT------VCNRRGVCDCA-AGEEGSQCSAER 1401
            |..|..|                     |...||.      .|:  |..||. :.:|...|....
Mouse  2843 CDGDNDCGDGSDENPIYCASHTCRSNEFQCVSPHRCIPSYWFCD--GEADCVDSSDEPDTCGHSL 2905

  Fly  1402 TGCSPGTFQCRSSGVCISWFFVCDGRADCNDASDEECTHNARLNQTCPTESFRCQRS-------- 1458
            ..||...|.| .:|.|||..:||||..||.|.|||:..|:..| |.|.:..|.|..|
Mouse  2906 NSCSANQFHC-DNGRCISSSWVCDGDNDCGDMSDEDQRHHCEL-QNCSSTEFTCINSRPPNRRCI 2968

  Fly  1459 ------------------------------------GRCISRAALCDGRRQCPHGEDELGCDGSV 1487
                                                ||||.::..||.|..|....||.||...
Mouse  2969 PQHWVCDGDADCADALDELQNCTMRACSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGCSYP- 3032

  Fly  1488 KGGNACPEHTFRCGSGECLPEYEYCNAIVSCKDGSDEPPHLCGSRALPNLFMRLIEAGGLLGGGR 1552
                .|.:..|.|.:|:|:.:...|:....|.|||||..|||
Mouse  3033 ----PCRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQEHLC----------------------- 3070

  Fly  1553 READAYCP---HRCSNGLCRSTAIVCSGRDGCGDGTDEQTCSVCRC 1595
            ...:..||   .||.||.|.....||:..|.|.|.:||:.|.:..|
Mouse  3071 HTPEPTCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGCGINEC 3116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_524849.2	EB	75..131	CDD:460294
		rne	<795..981	CDD:236766
		LDLa	1404..1437	CDD:238060	17/32 (53%)
		LDLa	1448..1483	CDD:238060	14/78 (18%)
		LDLa	1493..1524	CDD:238060	10/30 (33%)
Lrp2	NP_001074557.1	LDLa	28..62	CDD:238060
		LDLa	67..99	CDD:197566
		LDLa	108..142	CDD:238060
		LDLa	148..179	CDD:238060
		LDLa	183..217	CDD:238060
		LDLa	222..256	CDD:238060
		LDLa	265..299	CDD:238060
		YncE	<427..576	CDD:442618
		LDL-receptor class B 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	435..477
		LDL-receptor class B 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	478..520
		LY	502..547	CDD:214531
		LDL-receptor class B 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	521..567
		LY	550..590	CDD:214531
		LDL-receptor class B 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	568..612
		FXa_inhibition	662..703	CDD:464251
		LDL-receptor class B 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	752..794
		LY	775..817	CDD:214531
		LDL-receptor class B 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	795..836
		LDL-receptor class B 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	837..880
		Ldl_recept_b	837..878	CDD:459654
		LY	863..903	CDD:214531
		LDL-receptor class B 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	881..924
		FXa_inhibition	980..1012	CDD:464251
		LDLa	1025..1059	CDD:238060
		Ldl_recept_a	1065..1101	CDD:395011
		LDLa	1110..1144	CDD:238060
		LDLa	1150..1184	CDD:238060
		LDLa	1188..1223	CDD:238060
		LDLa	1231..1263	CDD:197566
		LDLa	1272..1306	CDD:238060
		LDLa	1313..1345	CDD:197566
		FXa_inhibition	1354..1389	CDD:464251
		EGF_CA	1391..1430	CDD:214542
		LDL-receptor class B 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1479..1521
		LY	1502..1544	CDD:214531
		LDL-receptor class B 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1522..1564
		LY	1546..1590	CDD:214531
		LDL-receptor class B 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1567..1610
		LY	1592..1633	CDD:214531
		LDL-receptor class B 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1611..1655
		LDL-receptor class B 13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1656..1696
		FXa_inhibition	1710..1741	CDD:464251
		LDL-receptor class B 14. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1791..1833
		LDL-receptor class B 15. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1834..1883
		LDL-receptor class B 16. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1884..1931
		Ldl_recept_b	1884..1929	CDD:459654
		LY	1912..1954	CDD:214531
		LDL-receptor class B 17. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1932..1973
		LDL-receptor class B 18. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1974..2014
		YncE	2035..2277	CDD:442618
		LDL-receptor class B 19. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2108..2157
		LDL-receptor class B 20. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2158..2202
		LY	2183..2226	CDD:214531
		LDL-receptor class B 21. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2203..2246
		LDL-receptor class B 22. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2247..2290
		LDL-receptor class B 23. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2291..2333
		FXa_inhibition	2347..2383	CDD:464251
		LDL-receptor class B 24. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2432..2478
		LY	2460..2501	CDD:214531
		LDL-receptor class B 25. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2479..2519
		LY	2503..2543	CDD:214531
		LDL-receptor class B 26. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2520..2563
		LDL-receptor class B 27. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2564..2605
		LY	<2595..2626	CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2606..2647
FXa_inhibition	2656..2693	CDD:464251
LDLa	2700..2732	CDD:197566
LDLa	2742..2776	CDD:238060
LDLa	2783..2818	CDD:238060
LDLa	2822..2855	CDD:197566	3/11 (27%)
LDLa	2865..2899	CDD:238060	8/35 (23%)
LDLa	2908..2939	CDD:197566	16/31 (52%)
LDLa	2950..2986	CDD:197566	4/35 (11%)
LDLa	2995..3029	CDD:238060	10/33 (30%)
LDLa	3034..3066	CDD:238060	11/31 (35%)
LDLa	3077..3111	CDD:238060	14/33 (42%)
FXa_inhibition	3124..3152	CDD:464251
vWFA	<3149..3192	CDD:469594
LY	3221..3262	CDD:214531
LDL-receptor class B 29. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3241..3283
LY	3264..3306	CDD:214531
Ldl_recept_b	3284..3332	CDD:459654
LDL-receptor class B 30. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3284..3326
LDL-receptor class B 31. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3335..3378
Ldl_recept_b	3335..3376	CDD:459654
LY	3360..3401	CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3379..3421
LY	3406..3443	CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3422..3462
FXa_inhibition	3471..>3500	CDD:464251
LDLa	3514..3548	CDD:238060
LDLa	3555..3586	CDD:197566
LDLa	3595..3627	CDD:197566
LDLa	3636..3668	CDD:197566
LDLa	3684..3716	CDD:238060
LDLa	3723..3756	CDD:238060
LDLa	3761..3795	CDD:238060
LDLa	3800..3834	CDD:238060
LDLa	3844..3876	CDD:238060
LDLa	3887..3917	CDD:197566
LDLa	3930..3964	CDD:238060
EGF_CA	4009..4049	CDD:214542
LY	4143..4178	CDD:214531
LDL-receptor class B 34. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4156..4198
LDL-receptor class B 35. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4199..4242
Ldl_recept_b	4199..4240	CDD:459654
LY	4224..4266	CDD:214531
LDL-receptor class B 36. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4244..4285
FXa_inhibition	4340..>4358	CDD:464251
SH3-binding. /evidence=ECO:0000255	4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4460..4465
Endocytosis signal. /evidence=ECO:0000255	4522..4527
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4558..4660
Interaction with DAB2. /evidence=ECO:0000250\|UniProtKB:P98164	4597..4610
NPXY motif	4603..4606
SH2-binding. /evidence=ECO:0000255	4606..4609
SH3-binding. /evidence=ECO:0000255	4619..4630
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.

DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpE1 and Lrp2

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.