Protein Alignment ImpE1 and LDLRAD3

DIOPT Version :10

• Sequence 1: NP_524849.2
• Gene: ImpE1 / 45879
• FlyBaseID: FBgn0001253
• Length: 1616
• Species: Drosophila melanogaster
• Sequence 2: NP_777562.1
• Gene: LDLRAD3 / 143458
• HGNCID: 27046
• Length: 345
• Species: Homo sapiens
• Alignment Length: 165
• Identity: 49/165 - (29%)
• Similarity: 72/165 - (43%)
• Gaps: 27/165 - (16%)

  Fly  1334 IPSASLAAIKPGTELRKRVDLGLEAVSLGLACSSDR------QCQLADPHTVCNRRGVCDCAAGE 1392
            :.||:.:.:.||.......:     :.....||:.|      ||.           |:.||....
Human    11 LSSAAESQLLPGNNFTNECN-----IPGNFMCSNGRCIPGAWQCD-----------GLPDCFDKS 59

  Fly  1393 EGSQCSAERTGCSPGTFQCRSSGVCISWFFVCDGRADCNDASDEE-CTHNARLNQTCPTESFRCQ 1456
            :..:|...::.|.|..|.|.|...||...|.|:|..||.|.|||| ||.|..|   |.|..:.|
Human    60 DEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLL---CSTARYHC- 120

  Fly  1457 RSGRCISRAALCDGRRQCPHGEDELGCDGSVKGGN 1491
            ::|.||.::.:|||:..|....||..|:.|.:.|:
Human   121 KNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGS 155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ImpE1	NP_524849.2	EB	75..131	CDD:460294
		rne	<795..981	CDD:236766
		LDLa	1404..1437	CDD:238060	15/32 (47%)
		LDLa	1448..1483	CDD:238060	12/34 (35%)
		LDLa	1493..1524	CDD:238060
LDLRAD3	NP_777562.1	(Microbial infection) Interaction with Venezuelan equine encephalitis virus/VEEV spike proteins E1 and E2. /evidence=ECO:0000269|PubMed:34646021	30..57		8/42 (19%)
		LDLa	32..64	CDD:238060	8/42 (19%)
		LDLa	71..106	CDD:238060	17/34 (50%)
		LDLa	113..147	CDD:238060	12/34 (35%)
		Involved in ITCH interaction. /evidence=ECO:0000269|PubMed:26854353	256..259
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..345
		Involved in ITCH interaction. /evidence=ECO:0000269|PubMed:26854353	275..278