Protein Alignment Hex-A and YLR446W

DIOPT Version :9

• Sequence 1: NP_524848.1
• Gene: Hex-A / 45875
• FlyBaseID: FBgn0001186
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_013551.1
• Gene: YLR446W / 851167
• SGDID: S000004438
• Length: 433
• Species: Saccharomyces cerevisiae
• Alignment Length: 491
• Identity: 105/491 - (21%)
• Similarity: 175/491 - (35%)
• Gaps: 160/491 - (32%)

  Fly    91 KSKMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLP---------N 146
            :|.:..|| :.|:|..:.:..:..:...||...|..:|            :..||         .
Yeast     4 ESTLAREL-ESLILPADSIVNVVDQFQEELLSRLQTNT------------ISMLPQCLVPDKRSR 55

  Fly   147 GNERGKFLALDLGGTNFRVLLIHLQE-----NNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLS 206
            .|...|.|.:|.|||..:..:|.|.:     |:.|::...|.          .:..|:.|...:.
Yeast    56 WNPEDKILTIDFGGTRLKFAIISLPQIVIEYNDAFELTYNIV----------DSNFFNQIIYTIC 110

  Fly   207 NFMAEHNVYKE--------RLPLGFTFSFPLRQLG----LTKGLLETWTKGFNCAGVVNEDVVQL 259
            ..:|.:...|:        :..:..||||||...|    :.||.:.|.|       :....|.||
Yeast   111 TRLAANGYIKKKNESSEASKFFVSVTFSFPLNPEGEVVAMGKGFVMTDT-------LQGSTVKQL 168

  Fly   260 LKDAIARRGDVQID-------VCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACY-------- 309
            ::.:..|.....|:       ||.::||.....::..:...|..|.||:|||.|||:
Yeast   169 IQSSFHRIISENIEEFFCTMNVCHVINDAIAVSLTSKFICENDSISLIIGTGTNACFEVPYGYLP 233

  Fly   310 ---MERVEEA--ELFAAEDPRKKHVLINTEWGAFGDNG-ALDFVRTEFDRDIDVHSINPGKQTFE 368
               .:.:.|.  ..:..|....||||||:|.|..|.|. ||        :..|:|.....:...|
Yeast   234 PFKRDALRETLPSSYNKETLNFKHVLINSEIGFIGKNVIAL--------QPFDIHGAISYEMPLE 290

  Fly   369 KMISGMYMGELVRLVLVKMTQAGIL-------FNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTN 426
            .:.||.::...::.:|:   |..|:       |||:                           ..
Yeast   291 CVTSGKWLPLSLKNILL---QYNIIPKNFPVEFNGE---------------------------LV 325

  Fly   427 CRLVLEELGLTNATDGDCANVRY-------ICE---CVSKRAAHLVSAGIATLINKMDEPT---- 477
            |:|.           .||.|..:       ||:   .:.||||..|:|    ::..:|..|
Yeast   326 CQLA-----------EDCTNAWFENEHYALICQIARLLIKRAAFYVAA----IVQAIDIITGCKN 375

  Fly   478 ---VTVGVDGS------VYRFHPKFHNLMVEKISQL 504
               :.:|..||      .||...|:::.:..|:..|
Yeast   376 YNFIHIGYVGSFLHNSNFYREQIKYYSSIHIKLQFL 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	46/227 (20%)
		Hexokinase_2	296..530	CDD:397683	57/253 (23%)
YLR446W	NP_013551.1	COG5026	1..433	CDD:227359	105/491 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910