DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-A and HXK1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_116711.3	Gene:	HXK1 / 850614	SGDID:	S000001949	Length:	485	Species:	Saccharomyces cerevisiae

Alignment Length:	465	Identity:	165/465 - (35%)
Similarity:	255/465 - (54%)	Gaps:	32/465 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFLALDLG 159
            :|:|.....:..|.::::....:.||.:||.|   ...|:.....:|.:.|.|.|.|.:||:|||
Yeast    27 IHQLEDMFTVDSETLRKVVKHFIDELNKGLTK---KGGNIPMIPGWVMEFPTGKESGNYLAIDLG 88

  Fly   160 GTNFRVLLIHLQENNDFQMESRIYAIPQHIMIGSGTQ--LFDHIAECLSNFMAEHNVY--KERLP 220
            |||.||:|:.|..|:.|......|.:| |.|..:..|  |:..||:.|.:||.|..:.  |:.||
Yeast    89 GTNLRVVLVKLSGNHTFDTTQSKYKLP-HDMRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLP 152

  Fly   221 LGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTL 285
            ||||||:|..|..:.:|:|:.|||||:...|...|||.||::.|::| ::.|::.|::|||.|||
Yeast   153 LGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKR-ELPIEIVALINDTVGTL 216

  Fly   286 MSCAWKNHNCKIGLIVGTGANACYMERVEEAELF---AAED-PRKKHVLINTEWGAFGDNGALDF 346
            ::..:.:...|:|:|.|||.|..:.:.|.:.|..   .|:| |....:.||.|:|:| ||..|..
Yeast   217 IASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSF-DNEHLVL 280

  Fly   347 VRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTK 411
            .||::|..:|..|..||:|.||||.||.|:|||:||||:::.:.|::...||...|....:..|.
Yeast   281 PRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTS 345

  Fly   412 YVSEIEADEPGNFTNCR----LVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINK 472
            |.:.|| |:|  |.|..    :..::.|: ..|..:...:|.:||.:..|||.|...|||.:..|
Yeast   346 YPARIE-DDP--FENLEDTDDIFQKDFGV-KTTLPERKLIRRLCELIGTRAARLAVCGIAAICQK 406

  Fly   473 MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFD-------LMLSEDGSGRGAALVAAV 530
            ....|..:..|||||..:|.|.....:.:..:.  |.|.|       ::.:|||||.|||::||:
Yeast   407 RGYKTGHIAADGSVYNKYPGFKEAAAKGLRDIY--GWTGDASKDPITIVPAEDGSGAGAAVIAAL 469

  Fly   531 ACREDILNGK 540
            : .:.|..||
Yeast   470 S-EKRIAEGK 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	74/198 (37%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	87/248 (35%)
HXK1	NP_116711.3	COG5026	6..477	CDD:227359	163/462 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343762
Domainoid	1	1.000	138	1.000	Domainoid score	I1047
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	270	1.000	Inparanoid score	I600
Isobase	1	0.950	-	0	Normalized mean entropy	S1223
OMA	1	1.010	-	-		QHG56451
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm9160
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2154
SonicParanoid	1	1.000	-	-		X170
TreeFam	1	0.960	-	-
	16	15.740