DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-A and HKL1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_175463.1	Gene:	HKL1 / 841468	AraportID:	AT1G50460	Length:	498	Species:	Arabidopsis thaliana

Alignment Length:	478	Identity:	147/478 - (30%)
Similarity:	249/478 - (52%)	Gaps:	45/478 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LSAAEKSKMVHELCQQLLLTDE------QVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDL 144
            :.:..|.:.|.|:.::  |.|:      :::::...:..|:..|||.:...|  :|..:|:|.||
plant    28 MKSRRKWRTVVEILKE--LEDDCDTPVGRLRQVVDAMAVEMHAGLASEGGSK--LKMLLTFVDDL 88

  Fly   145 PNGNERGKFLALDLGGTNFRVLLIHLQENN---DFQMESRIYAIPQHIMIGSGTQLFDHIAECLS 206
            |.|.|:|.:.||.||||.||:|.:.|.:..   |.|...| :.||.|:|..:...||:.:|..|.
plant    89 PTGREKGTYYALHLGGTYFRILRVLLGDQRSYLDVQDVER-HPIPSHLMNSTSEVLFNFLAFSLE 152

  Fly   207 NFMAEHNVYKE----RLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARR 267
            .|:.:.....:    |..|.||||||::...::.|:|..|||||..:.:|.:|:.:.|:.|:.||
plant   153 RFIEKEENGSDSQGVRRELAFTFSFPVKHTSISSGVLIKWTKGFEISEMVGQDIAECLQGALNRR 217

  Fly   268 GDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLIN 332
            | :.:.|.|::|||.|.|....:.:.:..:.::.|||:||||:||.:..............:::|
plant   218 G-LDMHVAALVNDTVGALSLGYYHDPDTVVAVVFGTGSNACYLERTDAIIKCQGLLTTSGSMVVN 281

  Fly   333 TEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQ 397
            .|||.|..:   ...||.:|.|:|..|.|.....|||||||||:|::||.|:::|::...:| |.
plant   282 MEWGNFWSS---HLPRTSYDIDLDAESSNANDMGFEKMISGMYLGDIVRRVILRMSEDSDIF-GP 342

  Fly   398 DSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLV 462
            .|.||:...:..|..||.|..|:.........:|:::|:::........|..||:.|::||..|.
plant   343 ISPVLSEPYVLRTNSVSAIHEDDTPELQEVARILKDIGVSDVPLKVRKLVVKICDVVTRRAGRLA 407

  Fly   463 SAGIATLINK-------------------MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPG 508
            :||||.::.|                   |.:.|| |.|:|.:|..:..|...|.|.:.:::...
plant   408 AAGIAGILKKIGRDGSGGITSGRSRSEIQMQKRTV-VAVEGGLYMNYTMFREYMEEALVEILGEE 471

  Fly   509 ITFDLMLS--EDGSGRGAALVAA 529
            ::..:::.  ||||..|:||:.|
plant   472 VSQYVVVKAMEDGSSIGSALLVA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	69/207 (33%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	77/255 (30%)
HKL1	NP_175463.1	PLN02362	1..498	CDD:215206	147/478 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.940