DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and HKL3

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_195497.1	Gene:	HKL3 / 829940	AraportID:	AT4G37840	Length:	493	Species:	Arabidopsis thaliana

Alignment Length:	454	Identity:	115/454 - (25%)
Similarity:	210/454 - (46%)	Gaps:	50/454 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RILHELRR--------------GLAKDTHPKANVKC------FVTYVQDLPNGNERGKFLALDLG 159
            |||.:..|              .|..|.......:|      .|::...||:|:|:|....::|.
plant    40 RILRKFARECATPVSKLWAVADALVADMTASLTAECCGSLNMLVSFTGSLPSGDEKGVHYGVNLR 104

  Fly   160 GTNFRVLLIHLQENND--FQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAEH--NVYKERLP 220
            |....:|...|..|.:  ..::.....||..::.||..:|.|.|:..|..|:|.:  ...:|...
plant   105 GKELLLLRGTLGGNEEPISDVQKHEIPIPDDVLNGSFKELCDFISLELVKFLAMNPGGEAEEVKN 169

  Fly   221 LGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGD--------VQIDVCAI 277
            ||||.:..:.|:|...      ....:...:.|:|..::|||.:....:        ::::. |:
plant   170 LGFTLTRSVEQIGSHS------ISSIHRKSLANDDDEKVLKDLVNDMNESLETHGLKIRMNT-AL 227

  Fly   278 LNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNG 342
            :::|.|.|....:.:.:....:.:|.|.||.|:|:.:|...:.:.....:.::::||||.|   .
plant   228 VDNTIGELAGGRYYHKDTVAAVSLGMGTNAAYIEQAQEISRWKSAIREPQEIVVSTEWGDF---R 289

  Fly   343 ALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGL 407
            :.....||||..:|..|:|||.:.||||:||.|:||:||.||:||::...||.......|....:
plant   290 SCHLPITEFDASLDAESLNPGHRIFEKMVSGRYLGEIVRRVLLKMSEESALFGDTLPPKLTIPYI 354

  Fly   408 FFTKYVSEIEAD--EPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLI 470
            .::..::.:..|  |.....|.:| .|..|:.::|......|..:|:.|::|||.|..|||..:|
plant   355 LWSPDMAAMHQDISEERETVNKKL-KEVFGIMDSTLAAREVVVEVCDVVAERAARLAGAGIVGMI 418

  Fly   471 NK---MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLML--SEDGSGRGAALVAA 529
            .|   :::....|.|:|.:|..:..|.|.:...:.:::...::..:::  |..||..||..:||
plant   419 KKLGRLEKKMSIVIVEGGLYDHYRVFRNYLHSSVWEMLGDELSDHVVIEHSHGGSAAGALFLAA 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	44/206 (21%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	71/241 (29%)
HKL3	NP_195497.1	PLN02596	1..490	CDD:178206	115/454 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	128	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.940