DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hex-A and ATHXK4

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_188639.2	Gene:	ATHXK4 / 821543	AraportID:	AT3G20040	Length:	502	Species:	Arabidopsis thaliana

Alignment Length:	462	Identity:	146/462 - (31%)
Similarity:	246/462 - (53%)	Gaps:	37/462 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KMVHELCQQLLLTDEQVQELCYRILHELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFLALD 157
            |.:.|.|:..|   .:::::...|..|::.||..:...|  :|..:|:|.|||||:|.|.:.||.
plant    42 KDLEEACETPL---GRLRQMVDAIAVEMQAGLVSEGGSK--LKMLLTFVDDLPNGSETGTYYALH 101

  Fly   158 LGGTNFRVLLIHL--QENNDFQMESRIYAIPQHIMIGSGTQLFDHIAECLSNFM-AEHNVYKERL 219
            |||:.||::.:||  |.::....:...::||..:|..:...|||.:|..|..|: .|.|.:....
plant   102 LGGSYFRIIKVHLGGQRSSLEVQDVERHSIPTSLMNSTSEVLFDFLASSLQRFIEKEGNDFSLSQ 166

  Fly   220 P----LGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILND 280
            |    |.||||||::|..::.|:|..|||||..:.:..||:.:.|:.|:.:|| :.|.|.|::||
plant   167 PLKRELAFTFSFPVKQTSISSGVLIKWTKGFAISEMAGEDIAECLQGALNKRG-LDIRVAALVND 230

  Fly   281 TTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELFAAEDPR--KKHVLINTEWGAFGDNGA 343
            |.|.|....:.:.:....::.|||:||||:||.:  .:...::||  ...:::|.|||.|..:
plant   231 TVGALSFGHFHDPDTIAAVVFGTGSNACYLERTD--AIIKCQNPRTTSGSMVVNMEWGNFWSS-- 291

  Fly   344 LDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLF 408
             ...||.:|.::|..|:|.....|||||.|||:|::||.|:::|:|...:| |..|.:|:|..:.
plant   292 -RLPRTSYDLELDAESMNSNDMGFEKMIGGMYLGDIVRRVILRMSQESDIF-GPISSILSTPFVL 354

  Fly   409 FTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGIATLINKM 473
            .|..||.:..|:.........:|::||::.........|..||:.|::|||.|.:||||.::.|:
plant   355 RTNSVSAMHEDDTSELQEVARILKDLGVSEVPMKVRKLVVKICDVVTRRAARLAAAGIAGILKKV 419

  Fly   474 DEP--------------TVTVGVDGSVYRFHPKFHNLMVEKISQLIKPGITFDLMLS--EDGSGR 522
            ...              ...|.|:|.:|..:..|...|.|.:..::...:...:::.  ||||..
plant   420 GRDGSGGGRRSDKQIMRRTVVAVEGGLYLNYRMFREYMDEALRDILGEDVAQHVVVKAMEDGSSI 484

  Fly   523 GAALVAA 529
            |:||:.|
plant   485 GSALLLA 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	69/201 (34%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	76/252 (30%)
ATHXK4	NP_188639.2	PLN02362	1..502	CDD:215206	146/462 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.940