DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hex-A and HXK2

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_179576.1	Gene:	HXK2 / 816505	AraportID:	AT2G19860	Length:	502	Species:	Arabidopsis thaliana

Alignment Length:	438	Identity:	151/438 - (34%)
Similarity:	235/438 - (53%)	Gaps:	42/438 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 ELRRGLAKDTHPKANVKCFVTYVQDLPNGNERGKFLALDLGGTNFRVLLIHLQENND------FQ 177
            |:..|||.:...|  :|..::||.:||:|:|.|.|.|||||||||||:.:.|...:|      |:
plant    65 EMHAGLASEGGSK--LKMLISYVDNLPSGDETGFFYALDLGGTNFRVMRVLLGGKHDRVVKREFK 127

  Fly   178 MESRIYAIPQHIMIGSGTQLFDHIAECLSNFMAE-----HNVYKERLPLGFTFSFPLRQLGLTKG 237
            .||    ||.|:|.|...:|||.|.:.|:.|:|.     |.....:..||||||||::||.|:.|
plant   128 EES----IPPHLMTGKSHELFDFIVDVLAKFVATEGEDFHLPPGRQRELGFTFSFPVKQLSLSSG 188

  Fly   238 LLETWTKGFNCAGVVNEDVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVG 302
            .|..|||||:....|::|||..|..|:.|.| :.:.|.|::|||.|||....:.|.:..:.:|:|
plant   189 TLINWTKGFSIDDTVDKDVVGELVKAMERVG-LDMLVAALVNDTIGTLAGGRYTNPDVVVAVILG 252

  Fly   303 TGANACYMERVEEAELFAAEDPRKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTF 367
            ||.||.|:||......:....|:...::||.|||.|..:   ....||:|..:||.|:|||:|..
plant   253 TGTNAAYVERAHAIPKWHGLLPKSGEMVINMEWGNFRSS---HLPLTEYDHSLDVDSLNPGEQIL 314

  Fly   368 EKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLE 432
            ||:|||||:||::|.||:||.:....|.......|....:..|..:|.:.:|     |:..|.:.
plant   315 EKIISGMYLGEILRRVLLKMAEEAAFFGDIVPPKLKIPFIIRTPNMSAMHSD-----TSPDLKVV 374

  Fly   433 ELGLTNATDGDCANVRY------ICECVSKRAAHLVSAGIATLINKMDEPTV--------TVGVD 483
            ...|.:..:...::::.      :|..::.|.|.|.:|||..::.|:.....        .:.:|
plant   375 GSKLKDILEVQTSSLKMRKVVISLCNIIASRGARLSAAGIYGILKKIGRDATKDGEAQKSVIAMD 439

  Fly   484 GSVYRFHPKFHNLMVEKISQLIKPGI--TFDLMLSEDGSGRGAALVAA 529
            |.::..:.:|...|...:.:|:...:  :.:::||.||||.||||:||
plant   440 GGLFEHYTQFSESMKSSLKELLGDEVSESVEVILSNDGSGVGAALLAA 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hex-A	NP_524848.1	Hexokinase_1	95..290	CDD:395278	77/181 (43%)
Hex-A	NP_524848.1	Hexokinase_2	296..530	CDD:397683	73/250 (29%)
HXK2	NP_179576.1	PLN02405	1..497	CDD:215226	151/438 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1565
eggNOG	1	0.900	-	-		E1_COG5026
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100530
Inparanoid	1	1.050	246	1.000	Inparanoid score	I1050
OMA	1	1.010	-	-		QHG56451
OrthoDB	1	1.010	-	-		D1153545at2759
OrthoFinder	1	1.000	-	-		FOG0000301
OrthoInspector	1	1.000	-	-		mtm1201
orthoMCL	1	0.900	-	-		OOG6_100418
Panther	1	1.100	-	-	O	PTHR19443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840