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Protein Alignment Hex-A and HKDC1

DIOPT Version :9

Sequence 1:	NP_524848.1	Gene:	Hex-A / 45875	FlyBaseID:	FBgn0001186	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_079406.4	Gene:	HKDC1 / 80201	HGNCID:	23302	Length:	917	Species:	Homo sapiens

Alignment Length:	481	Identity:	211/481 - (43%)
Similarity:	307/481 - (63%)	Gaps:	28/481 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ATTNATTATATTTNLTTHSPQQIALLSAAEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLA 125
            :|..|...||..:.:..             :.|.:..:.....||.||:.::..::..||..||.
Human   449 STKGAAMVTAVASRVQA-------------QRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLK 500

  Fly   126 KDTHPKANVKCFVTYVQDLPNGNERGKFLALDLGGTNFRVLLIHLQE-NNDFQMESRIYAIPQHI 189
            |.:|..|.|:...|||..||:|.|:|||||||||||||||||:.::. ....:|.::|:|||..|
Human   501 KKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEI 565

  Fly   190 MIGSGTQLFDHIAECLSNFMAEHNVYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNE 254
            |.|:|.:|||||.:|:::|:....:....||||||||||.||:.:.||.|..|||||.......|
Human   566 MQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGE 630

  Fly   255 DVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCKIGLIVGTGANACYMERVEEAELF 319
            |||.:|::||.||.:..:|:.|::|||.||:|:|.:::.||:||||.|||:|.||||.:...|:.
Human   631 DVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMV 695

  Fly   320 AAEDPRKKHVLINTEWGAFGDNGALDFVRTEFDRDIDVHSINPGKQTFEKMISGMYMGELVRLVL 384
            ...:.:   :.||||||.|||||.:|.:.|.:|.::|..|:|||||.:|||.||||:||:||.:|
Human   696 EGGEGK---MCINTEWGGFGDNGCIDDIWTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQIL 757

  Fly   385 VKMTQAGILFNGQDSEVLNTRGLFFTKYVSEIEADEPGNFTNCRLVLEELGLTNATDGDCANVRY 449
            :.:|:.|:||.||.||.|.|||:|.||::|:||:|... ....|.:|::||| ::|..|...|:.
Human   758 IDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLA-LLQVRRILQQLGL-DSTCEDSIVVKE 820

  Fly   450 ICECVSKRAAHLVSAGIATLINK------MDEPTVTVGVDGSVYRFHPKFHNLMVEKISQLI-KP 507
            :|..||:|||.|..||:|.::.|      ::...:||||||::|:.||.|..::.|.:.:|. :.
Human   821 VCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRC 885

  Fly   508 GITFDLMLSEDGSGRGAALVAAVACR 533
            .:||  ||||||||:||||:.|||.|
Human   886 DVTF--MLSEDGSGKGAALITAVAKR 909

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.